196403-57-3Relevant academic research and scientific papers
Synthesis of the trifluoromethylated retinoial aromatic amide - 4-[1-(5,6,7,8-tetrahydro-3-trifluoromethyl-5,5,8,8-tetramethyl-2-naphthalenyl) carbamoyl]benzoic acid
Qing, Feng-Ling,Fan, Junfa
, p. 159 - 161 (1999)
A new methodology was developed for the preparation of an o-trifluoromethylated arylamine. The condensation of 2-amino-3-trifluoromethyl-5,6,7,8-tetrahydro-5,5,8,8-tetramethylnaphthalene and terephthalic acid monomethyl ester chloride gave the trifluoromethylated retinoial aromatic amide. The key step in the synthesis is the introduction of the aryl trifluoromethyl group.
A Suzuki coupling approach to trifluoromethyl derivative of targretin (LGD 1069)
Qing, Feng-Ling,Fan, Junfa
, p. 2117 - 2120 (2007/10/03)
The palladium-catalyzed Suzuki coupling reaction σ-trinuoromethylated arylboronic acid 4 and vinyl triflate 5 provided the trifluoromethyl derivative of Targretin (LGD1069).
