245369-52-2

Upstream product

• 196403-57-3 2-Nitro-3-trifluoromethyl-5,6,7,8-tetrahydro-5,5,8,8-tetramethylnaphthalene 
• 116233-18-2 2-Bromo-3-nitro-5,6,7,8-tetrahydro-5,5,8,8-tetramethylnaphthalene 
• 27452-17-1 6-bromo-1,2,3,4-tetrahydro-1,1,4,4-tetramethylnaphthalene 
• 6223-78-5 2,5-dichloro-2,5-dimethyl hexane 
• 108-86-1 bromobenzene 

Relevant academic research and scientific papers

Synthesis of the trifluoromethylated retinoial aromatic amide - 4-[1-(5,6,7,8-tetrahydro-3-trifluoromethyl-5,5,8,8-tetramethyl-2-naphthalenyl) carbamoyl]benzoic acid

A new methodology was developed for the preparation of an o-trifluoromethylated arylamine. The condensation of 2-amino-3-trifluoromethyl-5,6,7,8-tetrahydro-5,5,8,8-tetramethylnaphthalene and terephthalic acid monomethyl ester chloride gave the trifluoromethylated retinoial aromatic amide. The key step in the synthesis is the introduction of the aryl trifluoromethyl group.