19647-69-9Relevant academic research and scientific papers
Strategy for O-alkylation of serine and threonine from serinyl and threoninyl acetic acids by photoinduced decarboxylative radical reactions: Connection between serine/threonine and carbohydrates/amino acids at the side chain
Yamamoto, Takashi,Iwasaki, Tomoya,Morita, Toshio,Yoshimi, Yasuharu
, p. 3702 - 3709 (2018/04/14)
O-Alkylations of serine and threonine derivatives at the hydroxy group were achieved using photoinduced decarboxylative radical reactions of serinyl and threoninyl acetic acids with an organic photocatalyst without racemization under mild conditions. Photoinduced decarboxylative radical additions of serinyl and threoninyl acetic acids to electron-deficient alkenes provided linked serine and threonine with carbohydrates and amino acids at the side chain. In addition, O-methylations containing deuterium and O-benzylation of serine were performed under similar photochemical conditions.
SPIRO-LACTAM NMDA MODULATORS AND METHODS OF USING SAME
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Page/Page column 54; 56, (2018/03/28)
Disclosed are compounds having potency in the modulation of NMDA receptor activity. Such compounds can be used in the treatment of conditions such as depression and related disorders. Orally delivered formulations and other pharmaceutically acceptable delivery forms of the compounds, including intravenous formulations, are also disclosed.
SPIRO-LACTAM AND BIS-SPIRO-LACTAM NMDA RECEPTOR MODULATORS AND USES THEREOF
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Page/Page column 87, (2018/03/28)
Disclosed are compounds having potency in the modulation of NMDA receptor activity. Such compounds can be used in the treatment of conditions such as depression and related disorders. Orally delivered formulations and other pharmaceutically acceptable delivery forms of the compounds, including intravenous formulations, are also disclosed.
