79009-37-3

Usage

Uses

Used in Pharmaceutical Industry:
H-THR-NHME is used as a building block for the development of novel peptides with specific properties for various pharmaceutical applications. The hydrophobic property introduced by the methyl group in H-THR-NHME can potentially enhance the bioavailability and stability of the peptides, making them more effective in drug delivery and targeting.
Used in Cosmetic Industry:
H-THR-NHME is used as an ingredient in cosmetic products for its potential moisturizing and skin conditioning properties. The polar nature of threonine and the hydrophobic property of the methyl group in H-THR-NHME can contribute to the overall effectiveness of cosmetic formulations, providing hydration and improving skin texture.
Used in Food Industry:
H-THR-NHME can be used as a functional ingredient in the food industry, where its unique combination of polar and hydrophobic properties can contribute to the development of innovative food products with improved taste, texture, and shelf life.
Used in Research and Development:
H-THR-NHME serves as a valuable research tool for scientists and researchers working in the fields of biochemistry, molecular biology, and drug discovery. Its unique properties can be utilized to study the interactions between peptides and other biomolecules, as well as to develop new therapeutic agents and diagnostic tools.

Upstream product

• 19647-69-9 benzyl ((2S,3R)-3-hydroxy-1-(methylamino)-1-oxobutan-2-yl)carbamate 
• 1072136-18-5 C₁₀H₂₀N₂O₄ 
• 72-19-5 L-threonine 
• 74-89-5 methylamine 

Downstream Products

• 126530-41-4 (S)-3-Hydroxy-N-methyl-2-(3-phenyl-thioureido)-butyramide 
• 141075-55-0 Cbz-Glycyl-allo-threonine N-methyl amide 
• 141075-56-1 ((4S,5R)-5-Methyl-4-methylcarbamoyl-4,5-dihydro-oxazol-2-ylmethyl)-carbamic acid benzyl ester 
• 141075-60-7 [(S)-1-((1S,2R)-2-Hydroxy-1-methylcarbamoyl-propylcarbamoyl)-2-methyl-propyl]-carbamic acid benzyl ester 
• 141075-62-9 [1-((1S,2R)-2-Hydroxy-1-methylcarbamoyl-propylcarbamoyl)-1-methyl-ethyl]-carbamic acid benzyl ester 
• 141075-57-2 Cbz-glycyl-threonine N-methyl amide 
• 141075-64-1 Cbz-prolyl-threonine N-methyl amide 
• 141194-97-0 [2-((2S,3S)-2-Methyl-3-methylcarbamoyl-aziridin-1-yl)-2-oxo-ethyl]-carbamic acid benzyl ester 
• 141075-61-8 [(S)-2-Methyl-1-((4S,5S)-5-methyl-4-methylcarbamoyl-4,5-dihydro-oxazol-2-yl)-propyl]-carbamic acid benzyl ester 
• 141075-63-0 [1-Methyl-1-((4S,5S)-5-methyl-4-methylcarbamoyl-4,5-dihydro-oxazol-2-yl)-ethyl]-carbamic acid benzyl ester 
• 141075-65-2 (S)-2-((4S,5S)-5-Methyl-4-methylcarbamoyl-4,5-dihydro-oxazol-2-yl)-pyrrolidine-1-carboxylic acid benzyl ester 
• 141075-58-3 ((4S,5S)-5-Methyl-4-methylcarbamoyl-4,5-dihydro-oxazol-2-ylmethyl)-carbamic acid benzyl ester 

Relevant academic research and scientific papers

SPIRO-LACTAM NMDA MODULATORS AND METHODS OF USING SAME

Disclosed are compounds having potency in the modulation of NMDA receptor activity. Such compounds can be used in the treatment of conditions such as depression and related disorders. Orally delivered formulations and other pharmaceutically acceptable delivery forms of the compounds, including intravenous formulations, are also disclosed.

SPIRO-LACTAM AND BIS-SPIRO-LACTAM NMDA RECEPTOR MODULATORS AND USES THEREOF

Disclosed are compounds having potency in the modulation of NMDA receptor activity. Such compounds can be used in the treatment of conditions such as depression and related disorders. Orally delivered formulations and other pharmaceutically acceptable delivery forms of the compounds, including intravenous formulations, are also disclosed.

Non-natural amino acids as modulating agents of the conformational space of model glycopeptides

The synthesis and conformational analysis in aqueous solution of different α-methyl-α-amino acid di-amides, derived from serine, threonine, β-hydroxycyclobutane-α-amino acids, and their corresponding model β-O-glucopeptides, are reported. The study reveals that the presence of an α-methyl group forces the model peptides to adopt helix-like conformations. These folded conformations are especially significant for cyclobutane derivatives. Interestingly, this feature was also observed in the corresponding model glucopeptides, thus indicating that the α-methyl group and not the β-O-glucosylation process largely determines the conformational preference of the backbone in these structures. On the other hand, atypical conformations of the glycosidic linkage were experimentally determined. Therefore, when a methyl group was located at the Cβ atom with an R configuration, the glycosidic linkage was rather rigid. Never-theless, when the S configuration was displayed, a significant degree of flexibility was observed for the glycosidic linkage, thus showing both alternate and eclipsed conformations of the ψb dihedral angle. In addition, some derivatives exhibited an unusual value for the Φ2 angle, which was far from a value of -60° expected for a conventional β-O-glycosidic linkage. In this sense, the different conformations exhibited by these molecules could be a useful tool in obtaining systems with conformational preferences "a la carte".

PREPARATION, SPECTRAL AND PHYSICOCHEMICAL CHARACTERISTICS OF METHYLAMIDE Nα-PHENYLTHIOCARBAMOYL DERIVATIVES OF NATURALLY OCCURING AMINO ACIDS

The methylamide Nα-phenylthiocarbamoyl derivatives of encoded amino acids II were prepared either by the addition of phenylisothiocyanate to amino acid methylamides or by the treatment of amino acid phenylthiohydantoins (5-alkyl-3-phenyl-2-thioxo-4-imidazolinones) I with methylamine.The derivatives were prepared of 19 amino acids and their melting points, 1H NMR, 13C NMR, mass, ultraviolet and infrared spectra were measured.