381221-89-2

Upstream product

• 10310-21-1 2-Amino-6-chloropurin 
• 381221-86-9 (E,Z)-2-benzyloxymethyl-1-bromo-1-bromomethyl-3,3-difluorocyclopropane 
• 381221-85-8 1-(3-Benzyloxymethyl-2,2-difluoro-cyclopropylmethylselanyl)-2-nitro-benzene 
• 196495-45-1 2-benzyloxymethyl-3,3-difluoro-1-methylenecyclopropane 
• 381221-90-5 2-amino-9-{[2-(benzyloxymethyl)-3,3-difluorocyclopropenyl]methyl}-6-chloropurine 

Relevant academic research and scientific papers

Methylene-gem-difluorocyclopropane analogues of nucleosides: Synthesis, cyclopropene-methylenecyclopropane rearrangement, and biological activity

Alkylation-elimination of adenine and 2-amino-6-chloropurine with gem-difluorocyclopropane dibromide 10 gave E- and Z-methylene-gem-difluorocyclopropane 11a, 11b, 12a, and 12b and gem-difluorocyclopropenes 13a and 13b. Debenzylation of intermediates 11a,

Synthesis and antiviral activity of methylenedifluorocyclopropane analogues of nucleosides

Synthesis and antiviral activity of methylenedifluorocyclopropane analogues 8a, 8b and 9a, 9b are described.