1966-65-0

Basic information

• Product Name: 1-PHENYL-4-METHYL-1-PENTYN-3-OL
• Synonyms: TIMTEC-BB SBB008968;TIMTEC-BB SBB008969;1-PHENYL-4-METHYL-1-PENTYN-3-OL;1-PHENYL-3-METHYL-1-PENTYN-3-OL;4-METHYL-1-PHENYL-PENT-1-YN-3-OL;4-METHYL-1-PHENYL-1-PENTYN-3-OL;3-METHYL-1-PHENYL-1-PENTYN-3-OL;3-methyl-1-phenylpent-1-yn-3-ol
• CAS NO: 1966-65-0
• Molecular Formula: C₁₂H₁₄O
• Molecular Weight: 174.24
• EINECS: 217-814-9
• Mol File: 1966-65-0.mol
• Article Data: 21

Chemical Properties

• Boiling Point: 277°Cat760mmHg
• Flash Point: 123.9°C
• Appearance: /
• Density: 1.02g/cm³
• Vapor Pressure: 0.00224mmHg at 25°C
• Refractive Index: 1.545
• CAS DataBase Reference: 1-PHENYL-4-METHYL-1-PENTYN-3-OL(CAS DataBase Reference)
• NIST Chemistry Reference: 1-PHENYL-4-METHYL-1-PENTYN-3-OL(1966-65-0)
• EPA Substance Registry System: 1-PHENYL-4-METHYL-1-PENTYN-3-OL(1966-65-0)

Safety Data

• Hazardous Substances Data: 1966-65-0(Hazardous Substances Data)

Usage

General Description

1-PHENYL-4-METHYL-1-PENTYN-3-OL is a chemical compound with the molecular formula C12H14O. It is a colorless liquid that is used in organic synthesis as a reagent for the preparation of various other chemical compounds. It is known for its ability to undergo reactions such as oxidation, reduction, and addition, making it versatile in terms of its synthetic applications. 1-PHENYL-4-METHYL-1-PENTYN-3-OL is also used in the pharmaceutical industry as an intermediate for the production of various drugs and pharmaceuticals. Additionally, it has potential applications in the field of materials science, such as in the production of polymers and other advanced materials.

InChI:InChI=1/C12H14O/c1-10(2)12(13)9-8-11-6-4-3-5-7-11/h3-7,10,12-13H,1-2H3

Upstream product

• 591-50-4 iodobenzene 
• 77-75-8 meparfynol 
• 6738-06-3 phenylethynylmagnesium bromide 
• 6804-29-1 1-Phenylaethinyl-1-<2-hydroxyaethoxy>-cyclopentan 
• 78-93-3 butanone 
• 536-74-3 phenylacetylene 
• 19307-74-5 1-phenyl-pent-1-yn-3-one 

Downstream Products

• 536-74-3 phenylacetylene 
• 78-93-3 butanone 
• 20125-66-0 1-phenyl-3-methyl-3-(triethylsilyl)oxy-1-pentyne 
• 1067324-31-5 3-methyl-1-phenylpenta-1,2-dien-1-yl diphenyl phosphine oxide 
• 40036-62-2 (3-methylpent-1-ynyl)benzene 
• 1620137-99-6 C₂₄H₄₂OSn 
• 96396-91-7 5-benzylidene-4,4-dimethyl-1,3-dioxolan-2-one 

Relevant articles and documents

Ru(ii)-catalyzed allenylation and sequential annulation of: N -tosylbenzamides with propargyl alcohols

We hereby report Ru(ii)-catalyzed C(sp2)-H allenylation of N-tosylbenzamides to access multi-substituted allenylamides. Furthermore, the allenylamides were converted to the corresponding isoquinolone derivatives via base mediated annulation. The current protocol features low catalyst loading, mild reaction conditions, high functional group compatibility and desired scalability. The unique functionality of the afforded allenes allowed further transformations to expand the practicality of the protocol. This journal is

Benzene-1,3,5-triyl Triformate (TFBen)-Promoted Palladium-Catalyzed Carbonylative Synthesis of 2-Oxo-2,5-dihydropyrroles from Propargyl Amines

In this letter, we developed a palladium-catalyzed procedure for the cyclocarbonylation of propargyl amines. Benzene-1,3,5-triyl triformate (TFBen) has been explored as the CO source and also as the key promotor. Various substituted 2-oxo-dihydropyrroles were produced in a facile manner in good yields (up to 90%).

Synthesis of 4-Oxoisoxazoline N-Oxides via Pd-Catalyzed Cyclization of Propargylic Alcohols with tert-Butyl Nitrite

A cyclization of propargylic alcohols with tert-butyl nitrite at room temperature in air was achieved using Pd(OAc)2 as catalyst. The first reported 4-oxoisoxazoline N-oxides could be directly accessed from a range of multisubstituted propargylic alcohols in moderate to excellent yields under mild conditions. Density functional theory calculations indicated that the reaction proceeds through a palladium-catalyzed NO2 addition that efficiently generates a ketoxime radical, which eventually produces 4-oxoisoxazoline N-oxide.