196604-54-3

Usage

Uses

Used in Pharmaceutical Synthesis:
3,5-di-O-benzyl-4-C-fluoromethyl-1,2-O-isopropylidene-α-D-ribofuranose is used as a key intermediate in the synthesis of pharmaceutical compounds for [application reason]. Its unique structure allows for the development of new drugs with potential therapeutic benefits.
Used in Medicinal Chemistry Research:
In the field of medicinal chemistry, 3,5-di-O-benzyl-4-C-fluoromethyl-1,2-O-isopropylidene-α-D-ribofuranose is used as a building block for the design and synthesis of novel bioactive molecules. Its fluoromethyl and benzyl groups can be further modified to explore structure-activity relationships and optimize drug candidates.
Used in Biochemical Studies:
3,5-di-O-benzyl-4-C-fluoromethyl-1,2-O-isopropylidene-α-D-ribofuranose is also utilized in biochemical research to investigate the interactions of modified sugars with proteins and enzymes. This can provide insights into the mechanisms of carbohydrate recognition and processing in biological systems.

Upstream product

• 63593-02-2 3-O-benzyl-1,2-O-isopropylidene-α-D-ribo-pentodialdo-1,4-furanose 
• 1013943-40-2 3-O-benzyl-1,2:5,6-di-O-isopropylidene-α-D-allofuranose 
• 620630-82-2 1,2 5,6-O-di(isopropylidene)-α-D-allofuranose 
• 100-39-0 benzyl bromide 
• 153186-10-8 ((3aR,5R,6S,6aR)-6-(benzyloxy)-5-((benzyloxy)methyl)-2,2-dimethyltetrahydrofuro[2,3-d][1,3]dioxol-5-yl)methanol 
• 63593-03-3 1,2-O-isopropylidene-3-O-benzyl-4-hydroxymethyl-α-D-ribofuranose 

Downstream Products

• 794517-51-4 1,2-di-O-acetyl-3,5-di-O-benzyl-4-C-(fluoromethyl)-α-D-ribofuranose 
• 196604-57-6 2'-O-acetyl-3',5'-di-O-benzyl-4'-C-fluoromethyluridine 
• 200066-88-2 1-((2R,3R,4S,5R)-4-Benzyloxy-5-benzyloxymethyl-5-fluoromethyl-3-hydroxy-tetrahydro-furan-2-yl)-1H-pyrimidine-2,4-dione 
• 196604-62-3 1-((2R,3S,4S,5R)-4-(benzyloxy)-5-((benzyloxy)methyl)-5-(fluoromethyl)-3-hydroxytetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione 
• 196604-52-1 4'-C-fluoromethylcytidine 
• 196604-52-1 1-(4-C-fluoromethyl-β-D-arabinofuranosyl)cytosine 
• 196604-56-5 1,2-di-O-acetyl-3,5-di-O-benzyl-4-C-fluoromethyl-D-ribofuranose 

Relevant academic research and scientific papers

NUCLEOTIDE AND NUCLEOSIDE THERAPEUTICS COMPOSITIONS AND USES RELATED THERETO

This disclosure relates to nucleotide and nucleoside therapeutic compositions and uses in treating infectious diseases, viral infections, and cancer, where the base of the nucleotide or nucleoside contains at least one thiol, thione or thioether.

NUCLEOTIDE AND NUCLEOSIDE COMPOSITIONS AND USES RELATED THERETO

This disclosure relates to nucleotide and nucleoside therapeutic compositions and uses in treating infectious diseases, viral infections, and cancer, where the base of the nucleotide or nucleoside contains at least one thiol, thione or thioether.

SUBSTITUTED NUCLEOSIDES, NUCLEOTIDES AND ANALOGS THEREOF

Disclosed herein are nucleosides, nucleotides and nucleotide analogs, methods of synthesizing the same and methods of treating diseases and/or conditions such as a Picornavirus and/or Flaviviridae infection with one or more nucleosides, nucleotides and nucleotide analogs.

SUBSTITUTED NUCLEOSIDES, NUCLEOTIDES AND ANALOGS THEREOF

Disclosed herein are nucleosides, nucleotides and nucleotide analogs, methods of synthesizing the same and methods of treating diseases and/or conditions such as a Coronaviridae virus, a Togaviridae virus, a Hepeviridae virus and/or a Bunyaviridae virus infection with one or more nucleosides, nucleotides and nucleotide analogs.

SUBSTITUTED NUCLEOSIDES, NUCLEOTIDES AND ANALOGS THEREOF

Disclosed herein are nucleosides, nucleotide analogs, methods of synthesizing nucleotide analogs and methods of treating diseases and/or conditions such as a Filoviridae virus infection with one or more nucleosides and/or nucleotide analogs.

Synthesis of 4'-C-fluoromethylnucleosides as potential antineoplastic agents

2-Deoxy-D-erythro-, ribo-, and arabino-pentofuranosylcytosines, which have a fluoromethyl group at the 4'-position, were synthesized. Introduction of fluorine was achieved by DAST treatment of 4-C-hydoxymethy]-D-ribofuranose, the key intermediate of 4'-C-methylnucleosides. Among these nucleosides, the 2'-deoxy derivative exhibited potent antineoplastic activity in vitro.