63593-02-2

Usage

Uses

Used in Organic Synthesis:
3-o-benzyl-1,2-o-isopropylidene-a-d-ribo-pentadialdo-1,4-furanose is used as a reactant or intermediate in organic synthesis for its unique structural properties and reactivity, facilitating the creation of various complex organic molecules.
Used in Pharmaceutical Development:
In the Pharmaceutical Industry, 3-o-benzyl-1,2-o-isopropylidene-a-d-ribo-pentadialdo-1,4-furanose is used as a key building block for the development of pharmaceuticals and other biologically active compounds. Its unique structure and functional groups make it a valuable component in the synthesis of novel drug candidates with potential therapeutic applications.
Used in Research and Development:
3-o-benzyl-1,2-o-isopropylidene-a-d-ribo-pentadialdo-1,4-furanose is also utilized in research and development settings to explore its chemical properties, reactivity, and potential applications in various chemical and biological processes. This helps in expanding the understanding of its role in organic chemistry and its potential uses in creating new compounds with specific functions.

Upstream product

• 70798-12-8 1,2-O-isopropylidene-3-O-benzyl-α-D-ribofuranoside 
• 20590-57-2 1,2-O-isopropylidene-5-O-trityl-α-D-ribofuranose 
• 40982-92-1 (3aR,5R,6R,6aR)-6-Benzyloxy-5-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-2,2-dimethyl-tetrahydro-furo[2,3-d][1,3]dioxole 
• 26597-74-0 1,2:5,6-di-O-isopropylidene-β-L-talofuranose 
• 2595-05-3 Diacetone D-glucose 
• 2847-00-9 1,2:5,6-di-O-isopropylidene-α-D-hexofuran-3-ulose 
• 582-52-5 1,2:5,6-di-O-isopropylidene-α-D-glucofuranose 
• 1013943-40-2 3-O-benzyl-1,2:5,6-di-O-isopropylidene-α-D-allofuranose 
• 620630-82-2 1,2 5,6-O-di(isopropylidene)-α-D-allofuranose 
• 100-39-0 benzyl bromide 
• 14686-89-6 (1,2:5,6)-di-O-isopropylidene-D-gulose 
• 22331-21-1 1,2:5,6-di-O-isopropylidene-3-O-benzyl-α-D-allofuranose 

Downstream Products

• 126854-87-3 (2R,4aR,6S,7R,8aR)-7-[(S)-((3aR,5R,6R,6aR)-6-Benzyloxy-2,2-dimethyl-tetrahydro-furo[2,3-d][1,3]dioxol-5-yl)-hydroxy-methyl]-6-methoxy-2-phenyl-tetrahydro-pyrano[3,2-d][1,3]dioxin-8-one 
• 117174-46-6 (3aR,5R,6R,6aR)-6-Benzyloxy-5-ethynyl-2,2-dimethyl-tetrahydro-furo[2,3-d][1,3]dioxole 
• 123802-70-0 3-O-benzyl-5-cyclohexylidene-5-deoxy-1,2-O-isopropylidene-α-D-ribofuranose 
• 124484-40-8 (S)-2-((3aR,5R,6R,6aR)-6-Benzyloxy-2,2-dimethyl-tetrahydro-furo[2,3-d][1,3]dioxol-5-yl)-2-hydroxy-acetamide 
• 124484-39-5 3-O-benzyl-1,2-O-isoprpylidene-β-L-talofuranuronamide 
• 117174-45-5 (E)-3-((3aR,5R,6R,6aR)-6-Benzyloxy-2,2-dimethyl-tetrahydro-furo[2,3-d][1,3]dioxol-5-yl)-1-((2S,3R,4S,5R,6R)-3,4,5-tris-benzyloxy-6-methoxy-tetrahydro-pyran-2-yl)-propenone 
• 120417-90-5 1,2-O-(methylethylidene)-3-O-(phenylmethyl)-α-D-ribofuranuroic acid 
• 161144-17-8 ethyl 3-O-benzyl-6-deoxy-1,2-O-isopropylidene-α-D-ribo-heptofuranuronate-5-ulose 
• 164213-49-4 (3aR,5R,6R,6aR)-6-Benzyloxy-5-(2,2-dibromo-vinyl)-2,2-dimethyl-tetrahydro-furo[2,3-d][1,3]dioxole 
• 159991-31-8 (E)-3-((3aR,5R,6R,6aR)-6-Benzyloxy-2,2-dimethyl-tetrahydro-furo[2,3-d][1,3]dioxol-5-yl)-acrylic acid methyl ester 
• 191721-03-6 (Z)-N-benzyl-(3-O-benzyl-1,2-O-isopropylidene-5-deoxy-α-D-ribofuranos-5-ylidene)amine N-oxide 
• 195875-23-1 (E)-3-((3aR,5R,6R,6aR)-6-Benzyloxy-2,2-dimethyl-tetrahydro-furo[2,3-d][1,3]dioxol-5-yl)-acrylic acid methyl ester 
• 207512-79-6 C₁₅H₁₉⁽²⁾HO₅ 
• 70492-77-2 3-O-benzyl-1,2-O-isopropylidene-α-D-ribopentadialdoximefuranose 

Relevant academic research and scientific papers

Synthesis of extended uridine phosphonates derived from an allosteric p2y2 receptor ligand

In this study we report the synthesis of C5/C6-fused uridine phosphonates that are structurally related to earlier reported allosteric P2Y2 receptor ligands. A silyl-Hilbert- Johnson reaction of six quinazoline-2,4-(1H, 3H)-dione-like base moie

Synthesis and in vitro anticancer activity of penaresidin-related stereoisomeric analogues

A straightforward route to penaresidin-based derivatives with an unsubstituted alkyl side chain was developed. To construct these stereoisomeric azetidene-derived alkaloids, [3,3]-sigmatropic rearrangements followed by late stage olefin cross metathesis and an intramolecular nucleophilic type substitution were involved as the key transformations. The protected D-ribofuranose was chosen as the sole chiral source. The ability of target molecules to inhibit cancer cells proliferation was evaluated on a panel of five malignant cell lines.

CYCLIC DINUCLEOTIDE COMPOUND AND USES THEREOF

Provided are a compound of formula (I), an optical isomer thereof, a pharmaceutically acceptable salt thereof, uses of said compound acting as a STING agonist.

NOVEL PROCESS FOR MAKING ALLOFURANOSE FROM GLUCOFURANOSE

The present invention relates to the manufacture of allofuranose from glucofuranose as defined in the description and in the claim. Allofuranos is an intermediate in the manufacture of oligonucleotides which can be used as a medicament.

From Oxygen to Sulfur and Back: Difluoro -H-phosphinothioates as a Turning Point in the Preparation of Difluorinated Phosphinates: Application to the Synthesis of Modified Dinucleotides

A simple, two-step procedure to convert α,α-difluorinated H-phosphinic acids into the corresponding H-phosphinothioates is described. The usefulness of these species is demonstrated by their transformation into difluorinated phosphinothioyl radicals and their addition onto alkenes. Additionally, sequential treatment of H-phosphinothioates by a strong base and a primary alkyl iodide constitutes an alternate route to the formation of the C-P bond. Both methods efficiently deliver difluorinated phosphinothioates. Similar reactions carried out with the fully oxygenated counterparts clearly indicate the superiority of the sulfur-based species and emphasize the crucial role played by sulfur in the construction of the second C-P bond. Oxidation easily transforms the thereby obtained phosphinothioates into the corresponding phosphinates. The whole strategy is applied to the stereoselective preparation of dinucleotide analogues featuring either a difluorophosphinothioyl or a difluorophosphinyl unit linking the two furanosyl rings.

Anaerobic 5-Hydroxybenzimidazole Formation from Aminoimidazole Ribotide: An Unanticipated Intersection of Thiamin and Vitamin B12 Biosynthesis

Comparative genomics of the bacterial thiamin pyrimidine synthase (thiC) revealed a paralogue of thiC (bzaF) clustered with anaerobic vitamin B12 biosynthetic genes. Here we demonstrate that BzaF is a radical S-adenosylmethionine enzyme that catalyzes the remarkable conversion of aminoimidazole ribotide (AIR) to 5-hydroxybenzimidazole (5-HBI). We identify the origin of key product atoms and propose a reaction mechanism. These studies represent the first step in solving a long-standing problem in anaerobic vitamin B12 assembly and reveal an unanticipated intersection of thiamin and vitamin B12 biosynthesis.

SUBSTITUTED NUCLEOSIDES, NUCLEOTIDES AND ANALOGS THEREOF

Disclosed herein are nucleosides, nucleotides and nucleotide analogs, methods of synthesizing the same and methods of treating diseases and/or conditions such as a Picornavirus and/or Flaviviridae infection with one or more nucleosides, nucleotides and nucleotide analogs.

SUBSTITUTED NUCLEOSIDES, NUCLEOTIDES AND ANALOGS THEREOF

Disclosed herein are nucleosides, nucleotide analogs, methods of synthesizing nucleotide analogs and methods of treating diseases and/or conditions such as a Filoviridae virus infection with one or more nucleosides and/or nucleotide analogs.

SUBSTITUTED NUCLEOSIDES, NUCLEOTIDES AND ANALOGS THEREOF

Disclosed herein are nucleosides, nucleotides and nucleotide analogs, methods of synthesizing the same and methods of treating diseases and/or conditions such as a Coronaviridae virus, a Togaviridae virus, a Hepeviridae virus and/or a Bunyaviridae virus infection with one or more nucleosides, nucleotides and nucleotide analogs.

Towards stable di-carba analogues of guanofosfocins

Guanofosfocins are strong inhibitors of chitin synthases, but also very prone to hydrolytic cleavage. Two advanced intermediates 15 and 20 for the synthesis of stable di-carba-guanofosfocins were prepared via ester 11. Acylation of the allylic C-glycoside