19685-11-1

Basic information

• Product Name: (S)-9-acetoxy-4-ethyl-4-hydroxy-1,12-dihydro-4H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14-dione
• Synonyms: (S)-9-acetoxy-4-ethyl-4-hydroxy-1,12-dihydro-4H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14-dione
• CAS NO: 19685-11-1
• Molecular Weight: 406.395
• Mol File: 19685-11-1.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (S)-9-acetoxy-4-ethyl-4-hydroxy-1,12-dihydro-4H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14-dione(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-9-acetoxy-4-ethyl-4-hydroxy-1,12-dihydro-4H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14-dione(19685-11-1)
• EPA Substance Registry System: (S)-9-acetoxy-4-ethyl-4-hydroxy-1,12-dihydro-4H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14-dione(19685-11-1)

Safety Data

• Hazardous Substances Data: 19685-11-1(Hazardous Substances Data)

Upstream product

• 86639-48-7 Camptothecin 1-oxide 
• 64-19-7 acetic acid 
• 53544-22-2 1,2,6,7-tetrahydrocamptothecin 
• 7689-03-4 camptothecin 

Relevant articles and documents

Process for preparing Topotecan from 10-hydroxy-4-(S) camptothecin

The present invention relates to the use of dihalomethanes as reagents for the preparation of Topotecan{4-(S)-10(dimethylamino)-methyl-4-ethyl 4,9 dihydroxyl-H-pyrano[3′4′:6,7]indolizino-[1,2-b]quinoline-3,14(4H,12H)dione} from 10-hydroxycamptothecin. The invention discloses the rationale use of dichloromethane under solid-liquid phase transfer catalysis, which can behave both as solvent and a reactant when it serves as a source for C-1 unit for amino-alkylation of 10-hydroxy-4-(S)camptothecin.