196859-68-4

Upstream product

• 14131-84-1 2,3:5,6-di-O-isopropylidene-α-D-mannofuranose 
• 54469-08-8 phenylmethyl 2,3:5,6-di-O-(1-methylethylidene)-α-D-mannofuranoside 
• 3458-28-4 D-Mannose 
• 74912-02-0 1-O-benzyl-2,3-O-isopropylidene-α-D-manno-furanose 
• 196859-67-3 benzyl 2,3-O-isopropylidene-5,6-O-sulfinyl-α-D-mannofuranoside 

Downstream Products

• 196859-69-5 benzyl 6-O-(3-deoxy-1,2:5,6-di-O-isopropylidene-α-D-glucofuranos-3-yl)-2,3-O-isopropylidene-α-D-mannofuranoside 
• 1428265-76-2 C₃₀H₃₄N₄O₅ 
• 1428265-77-3 C₃₂H₃₈N₄O₆ 
• 1428265-78-4 C₃₃H₄₀N₄O₆ 
• 1428265-79-5 C₃₂H₃₈N₄O₇ 
• 1428265-80-8 C₂₀H₂₄N₄O₅ 
• 1428265-81-9 C₂₂H₂₈N₄O₆ 
• 1428265-82-0 C₂₃H₃₀N₄O₆ 
• 1428265-83-1 C₂₂H₂₈N₄O₇ 
• 1428265-72-8 C₃₀H₃₃N₄O₈S^(1-)*Na⁽¹⁺⁾ 
• 1428265-73-9 C₃₂H₃₇N₄O₉S^(1-)*Na⁽¹⁺⁾ 
• 1428265-74-0 C₃₃H₃₉N₄O₉S^(1-)*Na⁽¹⁺⁾ 
• 1428265-75-1 C₃₂H₃₇N₄O₁₀S^(1-)*Na⁽¹⁺⁾ 

Relevant academic research and scientific papers

Design, synthesis and pharmacological evaluation of omeprazole-like agents with anti-inflammatory activity

A new series of novel benzimidazole derivatives containing substituted pyrid-2-yl moiety and polyhydroxy sugar conjugated to the N-benzimidazole moiety has been synthesized and evaluated as orally bioavailable anti-inflammatory agents with anti-ulcerogenic activity. The anti-inflammatory and anti-ulcerogenic activities of these compounds were compared to diclofenac and omeprazole, respectively. In carrageenan-induced paw oedema assay, 2-methyl-N-((3,4-dimethoxypyridin-2-yl)methyl)-1H-benzimidazol-5-amine (12d) and 1-(1,2,3,5-tetrahydroxy-α-d-mannofuranose)-5-(((3,4-dimethoxypyridin-2yl) methyl)amino)-2-methyl-1H-benzimidazole (15d) displayed dose-dependent anti-inflammatory activities by decreasing the inflammation by 62% and 72%, respectively which is comparable to that of diclofenac (73%). In contrast to diclofenac, the anti-inflammatory activity of these compounds was not only free from any side effects on the gastric mucosa but also showed significant anti-ulcerogenic activity in rat pyloric ligation and ethanol-induced gastric ulcer models similar to that of omeprazole. Together, these findings suggest that 12d and 15d are potent anti-inflammatory agents with concurrent anti-ulcerogenic activity and support its clinical promise as a component of therapeutic strategies for inflammation, for which the gastric side effects are always a major limitation.

Synthesis of ether linked pseudo-oligosaccharides via 5,6-cyclic sulfate derivatives of protected manno and glucofuranose

C-6 ring opening of 5,6-cyclic sulfate derivatives of protected manno and glucofuranose with carbohydrate alkoxides gave ether linked pseudo-di or trisaccharides. Use of methyl 2,3-O-isopropylidene-5,6-O-sulfuryl-α-D-mannofuranoside 1 led to protected pseudo-disaccharide D-Glcf-(3→6)-D-Manf-(5→6)-D-Manf4 and protected pseudo-trisaccharide D-Manf-(6→3)-D-Glcf-(6→3)-D-Glcf 11 derivatives in 66% and 41% overall yields, respectively.