196959-50-9Relevant academic research and scientific papers
Imidazo[l,2-b]pyridazines. XXIII Some 5-Deaza Analogues. Syntheses of Some 2- Aryl-6-(chloro, methoxy or unsubstituted)-3-(variously substituted)imidazo[l,2-a]pyridines and Their Affinity for Central and Mitochondrial Benzodiazepine Receptors
Schmitt, Martine,Bourguignon, Jean-Jacques,Barlin, Gordon B.,Davies, Les P.
, p. 719 - 725 (2007/10/03)
The syntheses of ethyl {2′-aryl-6′-(chloro, methoxy and unsubstituted)imidazo[l,2-a]pyridin-3′-yl}-2-(acylamino, acetoxy and hydroxy)acetates, 3-benzamidomethyl-2-benzoyl-6-(chloro and methoxy)imidazo[l,2-a]pyridines, 3-amino-6-chloro-2-phenylimidazo[l,2-a]pyridine and ethyl 2-(2′-phenylimidazo[l,2-a]pyridin-3′-yl)acetate are reported. The ability of these compounds to displace [3H]diazepam from central and mitochondrial (peripheral-type) benzodiazepine receptors has been examined. Ethyl 2-benzamido-2-{6′-chloro-2′-(4″-chlorophenyl)imidazo[l,2-a] pyridin-3′-yl}acetate (21) was selective for peripheral-type receptors (IC50 13 nM) but none bound strongly to central receptors.
Imidazopyridine derivatives and compositions containing them
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, (2008/06/13)
Imidazo[1,2-a]pyridine derivatives of the general formula (I) STR1 wherein Y1 represents hydrogen, halogen or (C1-4) alkyl, Y2 represents --SR in which R is hydrogen, (C1-4) alkyl or (4-alkoxyphenyl)methyl or hydroxy or (C1-4) alkoxy, X represents hydrogen, halogen, (C1-4) alkoxy, (C1-4) alkyl, --CF3, --CH3 S, --NO2 or --NH2, and R1 and R2, which may be the same or different, represent hydrogen or (C1-4) alkyl have useful therapeutic properties.
