197016-28-7

Upstream product

• 518-28-5 podofilox 
• 908355-89-5 Methanesulfonic acid (5R,5aR,8aR,9R)-8-oxo-9-(3,4,5-trimethoxy-phenyl)-5,5a,6,8,8a,9-hexahydro-furo[3',4':6,7]naphtho[2,3-d][1,3]dioxol-5-yl ester 

Downstream Products

• 171822-35-8 C₂₂H₂₁NO₇ 
• 155252-35-0 4β-amino-4-deoxypodophyllotoxin 
• 117507-84-3 (5R,5aR,8aS,9S)-9-amino-5-(4-hydroxy-3,5-dimethoxyphenyl)-5,5a,8a,9-tetrahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-6(8H)-one 

Relevant academic research and scientific papers

Stereo and chemoselective enzymatic reduction of azido functionality: Synthesis of 4-β-Aminopodophyllotoxin congeners by Baker's yeast

4β-Aminopodophyllotoxin congeners have been synthesized by the stereoselective biocatalytic reduction of the 4-azidopodophyllotoxins employing baker's yeast in excellent yields under mild conditions.

Facile and improved synthesis of 4β-aminopodophyllotoxin congeners

An efficient synthesis of 4β-aminopodophyllotoxin from 4β- bromopodophyllotoxin using ammonia, and also a facile synthesis of 4β- amino-4'-O-demethylpodophyllotoxin from 4β-azidopodophyllotoxin by simultaneous azido reduction and selective demethylation at 4'-position employing chlorotrimethylsilane and sodium iodide, has been described. These are potential precursors for the various 4β-amino analogs of podophyllotoxin possessing DNA topoisomerase II inhibition activity.