908355-89-5

Upstream product

• 124-63-0 methanesulfonyl chloride 
• 518-28-5 podofilox 

Downstream Products

• 155252-34-9 4β-azido-4-deoxypodophyllotoxin 
• 1359033-93-4 4α-(4-methyl-1H-imidazol-1-yl)-4-desoxypodophyllotoxin 
• 1359033-89-8 4α-(2-methyl-1H-imidazol-1-yl)-4-desoxypodophyllotoxin 
• 1359033-95-6 4β-(1H-imidazol-1-yl)-4-desoxypodophyllotoxin 
• 117507-84-3 (5R,5aR,8aS,9S)-9-amino-5-(4-hydroxy-3,5-dimethoxyphenyl)-5,5a,8a,9-tetrahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-6(8H)-one 
• 155325-18-1 4β-amino-4-deoxy-epipodophyllotoxin 
• 155252-35-0 4β-amino-4-deoxypodophyllotoxin 
• 197016-28-7 (5R,5aR,8aS)-9-Azido-5-(3,4,5-trimethoxy-phenyl)-5,8,8a,9-tetrahydro-5aH-furo[3',4':6,7]naphtho[2,3-d][1,3]dioxol-6-one 

Relevant academic research and scientific papers

Facile and improved synthesis of 4β-aminopodophyllotoxin congeners

An efficient synthesis of 4β-aminopodophyllotoxin from 4β- bromopodophyllotoxin using ammonia, and also a facile synthesis of 4β- amino-4'-O-demethylpodophyllotoxin from 4β-azidopodophyllotoxin by simultaneous azido reduction and selective demethylation at 4'-position employing chlorotrimethylsilane and sodium iodide, has been described. These are potential precursors for the various 4β-amino analogs of podophyllotoxin possessing DNA topoisomerase II inhibition activity.

Synthesis of new chiral N-heterocyclic carbenes from naturally occurring podophyllotoxin and their application to asymmetric allylic alkylation

Chiral N-heterocyclic carbenes (NHC) were synthesized from naturally occurring podophyllotoxin. Their coordination with [(η3-allyl)Pd(Br)]2 afforded (NHC)Pd(allyl)Br complexes, whose structures were unambiguously established by X-ray

Synthesis and biological evaluation of 4α/4β-imidazolyl podophyllotoxin analogues as antitumor agents

A series of 4α/4β-imidazolyl podophyllotoxin analogues have been designed and synthesized. All of the compounds were evaluated for their anticancer activity against a panel of three human cancer cell lines. Within the cell lines tested, some of the synthe

Synthesis of 4beta-amido and 4beta-sulphonamido analogues of podophyllotoxin as potential antitumour agents.

The new 4beta-amido analogues of podophyllotoxin or 4'-O-demethylepipodophyllotoxin have been prepared either by the coupling of 4beta-amino podophyllotoxin or 4beta-amino-4'-O-demethyl epipodophyllotoxin with the corresponding acids in presence of DCC in dichloromethane or by treating the appropriate acid chloride or sulphonyl chloride in presence of Et(3)N. These 4beta-amido and 4beta-sulphonamido derivatives of podophyllotoxin have been evaluated for their cytotoxicity against six human cancer cell lines. Some of these analogues have shown promising anticancer activity.

Stereo and chemoselective enzymatic reduction of azido functionality: Synthesis of 4-β-Aminopodophyllotoxin congeners by Baker's yeast

4β-Aminopodophyllotoxin congeners have been synthesized by the stereoselective biocatalytic reduction of the 4-azidopodophyllotoxins employing baker's yeast in excellent yields under mild conditions.