197146-85-3

Upstream product

• 100-52-7 benzaldehyde 
• 3373-59-9 L-threonine methyl ester 
• 50-00-0 formaldehyd 
• 196862-32-5 methyl (2S,3R)-2-(benzylamino)-3-hydroxybutanoate 
• 40216-78-2 (2S,3R)-3-Hydroxy-2-{[1-phenyl-meth-(E)-ylidene]-amino}-butyric acid methyl ester 

Downstream Products

• 197146-87-5 (4R,5S)-5-{(S)-1-[((1S,2R)-2-Hydroxy-1-methoxycarbonyl-propyl)-methyl-carbamoyl]-ethyl}-4-methyl-2-phenyl-oxazolidine-3-carboxylic acid tert-butyl ester 
• 95599-23-8 N-methyl-L-threonine methyl ester 

Relevant academic research and scientific papers

Preparation of the optically pure N-methyl amino ester method and product

The invention belongs to the field of organic synthesis of amino acids and discloses a method for preparing optically pure N-methyl amino-acid ester. The method comprises the following steps of carrying out esterification reaction on amino acid as a starting raw material and aldehyde to form an imine intermediate, carrying out reductive amination in the presence of palladium carbon, and carrying out hydrogenation and debenzylation to finally synthesize optically pure N-methyl amino-acid ester. The method has the advantages of simplicity in method, mild reaction conditions and good adaptability and side chains of D-type or L-type amino acid do not need to be protected.

Facile synthesis of highly functionalized N-methyl amino acid esters without side-chain protection

(Chemical Equation Presented) The facile, two-pot synthesis of N-methyl amino acid esters by way of reductive amination is presented. Side chain protection schemes are not required, the starting materials are all commercially available, and the synthetic

N-methyl threonine analogues of deglycobleomycin A2: Synthesis and evaluation

The synthesis of 5 and its D-allo-threonine epimer 6 and the comparison of their DNA cleavage efficiency and selectivity with that of deglycobleomycin A2 (3) are detailed. The studies illustrate that N-methylation of the L-threonine subunit wit