19716-56-4

Basic information

• Product Name: 1-BENZYL-1,2,3,4-TETRAHYDROISOQUINOLINE
• Synonyms: 1,2,3,4-tetrahydro-1-(phenylmethyl)isoquinoline;(RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline
• CAS NO: 19716-56-4
• Molecular Formula: C₁₆H₁₇N
• Molecular Weight: 223.3206
• Product Categories: chem-chemical
• Mol File: 19716-56-4.mol
• Article Data: 22

Chemical Properties

• Boiling Point: 358.7 °C at 760 mmHg
• Flash Point: 180.1 °C
• Appearance: /
• Density: 1.06 g/cm³
• Vapor Pressure: 2.5E-05mmHg at 25°C
• Refractive Index: 1.588
• CAS DataBase Reference: 1-BENZYL-1,2,3,4-TETRAHYDROISOQUINOLINE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-BENZYL-1,2,3,4-TETRAHYDROISOQUINOLINE(19716-56-4)
• EPA Substance Registry System: 1-BENZYL-1,2,3,4-TETRAHYDROISOQUINOLINE(19716-56-4)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 19716-56-4(Hazardous Substances Data)

Usage

General Description

1-Benzyl-1,2,3,4-tetrahydroisoquinoline is a chemical compound with the molecular formula C16H17N. It is a tetrahydroisoquinoline derivative with a benzyl group attached to the nitrogen atom. 1-BENZYL-1,2,3,4-TETRAHYDROISOQUINOLINE has been studied for its potential pharmacological properties, including its potential as a dopamine D1 receptor agonist and its inhibitory effects on the enzyme monoamine oxidase. It is also being investigated for its potential use in the treatment of conditions such as Parkinson's disease and depression. Additionally, 1-benzyl-1,2,3,4-tetrahydroisoquinoline has been studied for its ability to inhibit the growth of cancer cells and its potential neuroprotective effects. Overall, this compound has shown promise as a potential therapeutic agent in biomedical research.

InChI:InChI=1/C16H17N/c1-2-6-13(7-3-1)12-16-15-9-5-4-8-14(15)10-11-17-16/h1-9,16-17H,10-12H2

Upstream product

• 6907-59-1 1-benzylisoquinoline 
• 102739-93-5 1-benzyl-2-hydroxy-1,2,3,4-tetrahydroisoquinoline 
• 81763-78-2 [1-(1-Benzyl-3,4-dihydro-1H-isoquinolin-2-yl)-meth-(E)-ylidene]-cyclohexyl-amine 
• 140367-61-9 3,4-dihydro-1-phenylmethyl-2(1H)-isoquinolinecarboxylic acid 1,1-dimethylethyl ester 
• 78702-61-1 2-bis(dimethylamino)phosphinoyl-1-benzyl-1,2,3,4-tetrahydroisoquinoline 
• 6921-34-2 benzylmagnesium chloride 
• 7647-01-0 hydrogenchloride 
• 64-17-5 ethanol 
• 24853-83-6 1-benzyl-3,4-dihydro-isoquinoline 
• 7664-93-9 sulfuric acid 
• 73179-52-9 1-benzyl-2-methyl-isoquinolinium; iodide 
• 78317-83-6 2-(4-methoxyphenyl)-1,2,3,4-tetrahydroisoquinoline 
• 66310-10-9 N-benzyl-2,4,6-triphenylpyridinium tetrafluoroborate 
• 100-46-9 benzylamine 

Downstream Products

• 96550-45-7 1-Benzyl-3,4-dihydro-1H-isoquinoline-2-carbonyl chloride 
• 1394957-84-6 (1S)-1-benzyl-2-(3-mesitylpropanoyl)-1,2,3,4-tetrahydroisoquinoline 
• 57680-86-1 (1S)-1-benzyl-1,2,3,4-tetrahydroisoquinoline 
• 57680-87-2 (1R)-1-benzyl-1,2,3,4-tetrahydroisoquinoline 
• 4831-01-0 1-benzyl-2,3-dihydro-1H-indene 
• 138967-33-6 1-phenylmethy-3,4-dihydro-1H-isoquinoline-2-carboxaldehyde 
• 138949-61-8 5,6-dihydrodibenzoquinolizinium chloride 
• 10225-29-3 1-benzyl-2-methyl-1,2,3,4-tetrahydroisoquinoline 
• 131-10-2 (-)-berbine 

Related news

Short communicationDeprenyl decreases an endogenous parkinsonism-inducing compound, 1-BENZYL-1,2,3,4-TETRAHYDROISOQUINOLINE (cas 19716-56-4) in mice: in vivo and in vitro studies09/08/2019

We examined the effect of deprenyl, a promising drug for the therapy of Parkinson's disease on the formation of a parkinsonism-inducing compound, 1-benzyl-1,2,3,4-tetrahydroisoquinoline (1BnTIQ). The 1BnTIQ content was significantly decreased in the brain of deprenyl-treated mouse in vivo, ...detailed

NeuropharmacologyResearch PaperSingle administration of 1-BENZYL-1,2,3,4-TETRAHYDROISOQUINOLINE (cas 19716-56-4) increases the extracellular concentration of dopamine in rat striatum09/05/2019

We performed a combined neurochemical and behavioral study to determine the effects of 1-benzyl-1,2,3,4-tetrahydroisoquinoline (1-BnTIQ) on the extracellular dopamine concentrations in the striatum. Single dose administration of 1-BnTIQ (20, 40, and 80 mg/kg i.p.) increased striatal dopamine ext...detailed

1-BENZYL-1,2,3,4-TETRAHYDROISOQUINOLINE (cas 19716-56-4) (1BnTIQ), An Endogenous Neurotoxin, Induces Dopaminergic Cell Death Through Apoptosis09/04/2019

Endogenous MPTP-like neurotoxins such as 1-benzyl-1,2,3,4-tetrahydroisoquinoline (1BnTIQ) have been suspected in the etiology of Parkinson’s disease (PD). 1BnTIQ was found in a concentration three times higher in cerebrospinal fluid of PD brains than control subjects [J. Neurochem. 65 (6) (1995...detailed

1-BENZYL-1,2,3,4-TETRAHYDROISOQUINOLINE (cas 19716-56-4) passes through the blood–brain barrier of rat brain: An in vivo microdialysis study08/31/2019

Previous work has established that 1-benzyl-1,2,3,4-tetrahydroisoquinoline (1-BnTIQ) causes a parkinsonian syndrome in rats. The present study reports the blood–brain barrier (BBB) permeability of 1-BnTIQ in freely moving rats with the aid of in vivo microdialysis-based measurements. The microd...detailed

Relevant articles and documents

Anionic Rearrangement of BF3-complexed N-Allyl and Aryl Tetrahydroisoquinolines.

BF3-complexed N-Allyl and N-benzyl tetrahydroisoquinolines react, at -20 deg C to 0 deg C in THF, with sec-BuLi to give 1-substituted tetrahydroisoquinolines.

Photocatalytic deaminative benzylation and alkylation of tetrahydroisoquinolines with N-alkylpyrydinium salts

A ruthenium-catalyzed photoredox coupling of substituted N-aryltetrahydroisoquinolines (THIQs) and different bench-stable pyridinium salts was successfully developed to give fast access to 1-benzyl-THIQs. Furthermore, secondary alkyl and allyl groups were also successfully introduced via the same method. Additionally, the typically applied N-phenyl group in the THIQ substrate could be replaced by the cleavable p-methoxyphenyl (PMP) group and successful N-deprotection was demonstrated.

4,5-Dihydrothiazoline - A new protecting and activating group for generation of α-aminocarbanions of secondary amines

4,5-Dihydrothiazoline has been successfully used as a protecting and activating group for synthesis of various 1-substituted 1,2,3,4- tetrahydroisoquinolines via a lithiation-electrophillic substitution reaction sequence. Copyright Taylor & Francis Group, LLC.