197229-68-8

Upstream product

• 501-53-1 benzyl chloroformate 
• 349544-22-5 N-(benzyloxycarbonyl)-(5R)-[((4S)-2,2-dimethyl-1,3-dioxolan-4-yl)methyl]pyrrolidine 
• 197230-34-5 (R)-2-allyl-(N-benzyloxycarbonyl) pyrrolidine 

Downstream Products

• 496-47-9 (+)-hygroline 
• 349544-23-6 N-(benzyloxycarbonyl)-(5R)-5-[(2S)-2-hydroxy-3-methanesulfonyloxyprop-1-yl]pyrrolidine 

Relevant academic research and scientific papers

Intramolecular amidomercurations under allylic control: A stereoselective synthesis of (+)-pseudohygroline and (+)-3-hydroxypyrrolizidine

The diastereoselectivity of intramolecular amidomercurations can be reversed by altering the remote allylic substituent of ω-alkenylcarbamates. This methodology has been applied to the synthesis of (+)-pseudohygroline and (+)-3-hydroxypyrrolizidine.

New synthesis of all the four isomers of 2-(2-hydroxypropyl)pyrrolidines via iterative asymmetric dihydroxylation to cause enantiomeric enhancement

Both enantiomers of 2-(2-propenyl)pyrrolidine 7 (75-84% ee), prepared via the asymmetric dihydroxylation (AD) of terminal olefin 5, underwent the second AD to provide all of the four stereoisomeric 2-(2-hydroxypropyl)pyrrolidines 8 with enantiomeric enhan