197231-57-5

Basic information

• Product Name: (1S,4'S)-N-tert-butoxycarbonyl-1-(2',2'-dimethyl-[1',3']-dioxolan-4'-yl)-3-phenylpropylamine
• Synonyms: (1S,4'S)-N-tert-butoxycarbonyl-1-(2',2'-dimethyl-[1',3']-dioxolan-4'-yl)-3-phenylpropylamine
• CAS NO: 197231-57-5
• Molecular Weight: 335.444
• Mol File: 197231-57-5.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (1S,4'S)-N-tert-butoxycarbonyl-1-(2',2'-dimethyl-[1',3']-dioxolan-4'-yl)-3-phenylpropylamine(CAS DataBase Reference)
• NIST Chemistry Reference: (1S,4'S)-N-tert-butoxycarbonyl-1-(2',2'-dimethyl-[1',3']-dioxolan-4'-yl)-3-phenylpropylamine(197231-57-5)
• EPA Substance Registry System: (1S,4'S)-N-tert-butoxycarbonyl-1-(2',2'-dimethyl-[1',3']-dioxolan-4'-yl)-3-phenylpropylamine(197231-57-5)

Safety Data

• Hazardous Substances Data: 197231-57-5(Hazardous Substances Data)

Upstream product

• 154079-56-8 (2S,3S)-3-diphenylmethylamino-5-phenyl-1,2-pentanediol 
• 154428-47-4 (2R,3R)-trans-2,3-epoxy-5-phenyl-1-pentanol 
• 75553-23-0 (E)-5-phenyl-2-penten-1-ol 
• 24424-99-5 di-tert-butyl dicarbonate 
• 448190-33-8 1-phenyl-(3S)-azido-(4R)-5-isopropylidene-1-pentene 
• 448190-32-7 1-phenyl-(3R)-hydroxy-(4R)-5-isopropylidene-1-pentene 
• 170028-87-2 D-xylose-(2R,3R,4R)-5-di-O-isopropylidene-[4-(methylphenyl)sulfonyl]hydrazone 
• 13039-94-6 2,3,4,5-di-O-isopropylidene-D-xylose aldehyde 
• 77-76-9 2,2-dimethoxy-propane 
• 154079-57-9 (2S,3S)-3-(tert-butoxycarbonylamino)-5-phenyl-1,2-pentanediol 
• 131319-74-9 (R)-2,3-di-O-isoproylideneglyceraldehyde N-benzylimine 
• 27846-25-9 1-phenyl-2-(phenylsulfonyl)ethane 

Downstream Products

• 92136-56-6 (2S)-[N-(tert-butoxycarbonyl)amino]-4-phenylmethyl butanoate 
• 82732-07-8 Boc-L-homophenylalanine 

Relevant articles and documents

Vinylsulfones versus alkylsulfones in the addition to chiral imines. Synthesis of N-(tert-butoxycarbonyl)-L-homophenylalanine

A study of the addition of vinylsulfones versus alkylsufones has been done, and applied to the synthesis of N-(tert-butoxycarbonyl)-L-homophenylalanine.

Enantioselective synthesis of (S)-Vigabatrin

An asymmetric synthesis of fully protected (S)-Vigabatrin has been developed. The key intermediate in the sequence is enantiomerically pure N-Boc-5-phenyl-3-amino-1,2-diol 5a, obtained from (E)-5-phenyl-2-penten-1-ol by employing a catalytic Sharpless epo