92136-56-6Relevant academic research and scientific papers
Nickel-Catalyzed Cross-Coupling of Amino-Acid-Derived Alkylzinc Reagents with Alkyl Bromides/Chlorides: Access to Diverse Unnatural Amino Acids
Gou, Fei-Hu,Ma, Ming-Jian,Wang, An-Jun,Zhao, Liang,Wang, Haoyang,Tong, Jie,Wang, Ze,Wang, Zhen,He, Chun-Yang
, p. 240 - 244 (2022/01/12)
Unnatural α-amino acids are important synthetic targets in the field of peptide science. Herein we report an efficient, versatile, and straightforward strategy for the synthesis of homophenylalanine derivatives via the nickel-catalyzed Csp3–Csp3 cross-coupling of (fluoro)benzyl bromides/chlorides with natural α-amino-acid-derived alkylzinc reagents. The current protocol features the advantages of a low-cost nickel catalyst system, synthetic convenience, and the tolerance of rich functionality and stereochemistry.
Cu(OTf)2-Promoted 1,4-addition of alkyl bromides to dehydroalanine
Shin, Jung-Ah,Kim, Jiheon,Lee, Hongsoo,Ha, Sura,Lee, Hee-Yoon
, p. 4558 - 4565 (2019/05/01)
Zn/Cu(OTf)2-mediated addition of alkyl bromides to dehydroalanine (Dha) derivatives including dipeptides and tripeptides in good to high yields under an aqueous medium was developed. This protocol allows selective and biocompatible access to various amino acid units from Dha derivatives.
N-ALKOXYAMIDE CONJUGATES AS IMAGING AGENTS
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, (2016/10/08)
The present disclosure is directed to compounds, diagnostic agents, and related methods. In some cases, methods for treating patients are provided. More specifically, the disclosure provides compounds, diagnostic agents, and kits for detecting and/or imaging and/or monitoring elastin rich tissues. In addition, the disclosure provides methods of detecting and/or imaging and/or monitoring the presence of coronary plaque, carotid plaque, iliac/femoral plaque, aortic plaque, renal artery plaque, plaque of any arterial vessel, aneurism, vasculitis, other diseases of the arterial wall, and/or damage or structural changes in ligaments, uterus, lungs or skin, as indicated by changes in total vessel wall area, internal lumen size, and exterior arterial perimeter.
N-alkoxyamide conjugates as imaging agents
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, (2016/06/01)
The present disclosure is directed to compounds, diagnostic agents, and related methods. In some cases, methods for treating patients are provided. More specifically, the disclosure provides compounds, diagnostic agents, and kits for detecting and/or imaging and/or monitoring elastin rich tissues. In addition, the disclosure provides methods of detecting and/or imaging and/or monitoring the presence of coronary plaque, carotid plaque, iliac/femoral plaque, aortic plaque, renal artery plaque, plaque of any arterial vessel, aneurism, vasculitis, other diseases of the arterial wall, and/or damage or structural changes in ligaments, uterus, lungs or skin, as indicated by changes in total vessel wall area, internal lumen size, and exterior arterial perimeter.
N-ALKOXYAMIDE CONJUGATES AS IMAGING AGENTS
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, (2011/02/24)
The present disclosure is directed to compounds, diagnostic agents, and related methods. In some cases, methods for treating patients are provided. More specifically, the disclosure provides compounds, diagnostic agents, and kits for detecting and/or imaging and/or monitoring elastin rich tissues. In addition, the disclosure provides methods of detecting and/or imaging and/or monitoring the presence of coronary plaque, carotid plaque, iliac/femoral plaque, aortic plaque, renal artery plaque, plaque of any arterial vessel, aneurism, vasculitis, other diseases of the arterial wall, and/or damage or structural changes in ligaments, uterus, lungs or skin, as indicated by changes in total vessel wall area, internal lumen size, and exterior arterial perimeter.
SELECTIVE INHIBITORS OF MMP-12
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, (2008/06/13)
The present invention provides novel mercaptoacetylamido dipeptide carboxylic acids of formula (1) which are MMP inhibitors useful for the treatment of smoking-induced emphysema.
Synthesis of unusual amino acids: N-(tert-butoxycarbonyl)-L-vinyl glycine and N-(tert-butoxycarbonyl)-L-homophenylalanine
Chandrasekhar,Raza, Abbas,Takhi, Mohamed
, p. 423 - 428 (2007/10/03)
The synthesis of the unusual amino acids N-(tert-butoxycarbonyl)-L-vinyl glycine and N-(tert-butoxycarbonyl)-L-homophenylalanine starting from commercially available D-xylose via an alkylative fragmentation method is described.
Selective inhibitors of MMP-12
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, (2008/06/13)
The present invention provides novel mercaptoacetylamido dipeptide carboxylic acids of the formula which are MMP inhibitors useful for the treatment of smoking-induced emphysema.
New synthesis and ring opening of cis-3-alkylaziridine-2-carboxylates
Lee, Kwang-Deuk,Suh, Jang-Min,Park, Jae-Hoon,Ha, Hyun-Joon,Choi, Hwan Gun,Park, Chan Sun,Chang, Jae Won,Lee, Won Koo,Dong, Yongkwan,Yun, Hoseop
, p. 8267 - 8276 (2007/10/03)
Syntheses of cis-3-alkylaziridine-2-carboxylates including cis-3-benzyl- and cis-3-phenylaziridine-2-carboxylates were achieved from the reaction of α-aminonitrile and alkyldiazoacetate in the presence of a Lewis acid. Asymmetric version of this reaction with the chiral α-methylbenzylamine was also successful for the preparation of chiral aziridines that were used for the synthesis of various amino acids including homophenylalanine, β-amino-α-hydroxy acid, α,β-diamino acid, and α-amino-β-hydroxy acid via regioselective aziridine ring openings.
Enantioselective enzyme catalysed ammoniolysis of amino acid derivatives. Effect of temperature
Lopez-Serrano, Paloma,Wegman, Margreth A.,Van Rantwijk, Fred,Sheldon, Roger A.
, p. 235 - 240 (2007/10/03)
The lipases from Candida antarctica (B type), Thermomyces lanuginosus and Pseudomonas alcaligenes catalysed the enantioselective ammoniolysis of free amino acid esters. In the ammoniolysis of phenylalanine methyl ester catalysed by T. lanuginosus lipase a
