197234-78-9Relevant academic research and scientific papers
Electron-density determination of electrophilic building blocks as model compounds for protease inhibitors
Grabowsky, Simon,Pfeuffer, Thomas,Checinska, Lilianna,Weber, Manuela,Morgenroth, Wolfgang,Luger, Peter,Schirmeister, Tanja
, p. 2759 - 2768 (2007)
Three types of synthesised compounds, the aziridine 1, the epoxide 2 and the acceptor-substituted olefin 3, were chosen as model compounds for electrophilic building blocks, which can covalently block the nucleophilic amino acids of the active sites of pr
A comparative study on the experimentally derived electron densities of three protease inhibitor model compounds
Grabowsky, Simon,Pfeuffer, Thomas,Morgenroth, Wolfgang,Paulmann, Carsten,Schirmeister, Tanja,Luger, Peter
body text, p. 2295 - 2307 (2009/02/02)
In order to contribute to a rational design of optimised protease inhibitors which can covalently block the nucleophilic amino acids of the proteases' active sites, we have chosen three model compounds (aziridine l, oxirane 2 and acceptor-substituted olef
