19725-47-4

Basic information

• Product Name: 2'-METHOXYFLAVONE
• Synonyms: TIMTEC-BB SBB005966;2'-METHOXYFLAVONE;METHOXYFLAVONE, 2'-
• CAS NO: 19725-47-4
• Molecular Formula: C₁₆H₁₂O₃
• Molecular Weight: 252.26
• Product Categories: Mono-substituted Flavones;Benzopyrans;Building Blocks;Chemical Synthesis;Heterocyclic Building Blocks
• Mol File: 19725-47-4.mol
• Article Data: 32

Chemical Properties

• Melting Point: 102-103°C
• Boiling Point: 410.4°Cat760mmHg
• Flash Point: 193.7°C
• Appearance: /
• Density: 1.24g/cm³
• CAS DataBase Reference: 2'-METHOXYFLAVONE(CAS DataBase Reference)
• NIST Chemistry Reference: 2'-METHOXYFLAVONE(19725-47-4)
• EPA Substance Registry System: 2'-METHOXYFLAVONE(19725-47-4)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 19725-47-4(Hazardous Substances Data)

Usage

General Description

2'-Methoxyflavone is a chemical compound which belongs to the group of flavonoids. Flavonoids are widely-distributed secondary metabolites with antioxidant, anti-inflammatory, antiviral, and anticancer activities. 2'-Methoxyflavone, specifically, is known for its potential health benefits and therapeutic applications. It has been studied for its apparent bioactive properties including antioxidant, anti-inflammatory, and anti-cancer activity. Its antioxidant properties may protect cells from damage, while its anti-inflammatory properties may help to reduce swelling and pain. Studies have also suggested that 2'-Methoxyflavone may help to inhibit the growth of cancer cells. However, the exact properties and potential benefits of 2'-Methoxyflavone still need further scientific research.

Upstream product

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• 22105-09-5 4‐hydroxycoumarin 
• 74-83-9 methyl bromide 
• 74-88-4 methyl iodide 
• 90-02-8 salicylaldehyde 
• 90585-32-3 1,1-dibromo-2-(2-methoxyphenyl)ethene 
• 31949-21-0 bromomethyl 2-methoxyphenyl ketone 
• 118-93-4 o-hydroxyacetophenone 

Downstream Products

• 153446-74-3 3-iodo-2-(2-methoxyphenyl)chromone 
• 98153-17-4 2-(2-Methoxyphenyl)-4-oxo-4H-1-benzopyran-3-carboxylic acid 
• 35244-11-2 2'-hydroxyflavone 

Relevant articles and documents

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OXYTHALLATION OF FLAVENES.I;DIRECT CONVERSION OF FLAVENES TO FLAVONES WITH THALLIUM(III) NITRATE.

Oxythallation of flav-2-enes and flav-3-enes with 2 moles equivalent of TTN in methanol gives flavones.

Synthesis and solid state self-assembly of a 1,4-diazepine derivative: Water cluster as molecular glue and conformational isomerism

Diazepine (a seven membered heterocycle) derivatives have emerged as “privileged structures” in chemical biology and medicinal chemistry. In this article, synthesis of a 1, 4-diazepine derivative 4 from flavone 3 in excellent yield is described. The solid state self-assembly pertaining to diazepine derivative 4 was investigated with X-ray crystallography. Fascinatingly, the solid state structure of 4 represents a remarkable example of water cluster acting as structural glue to instigate conformational isomerism and hence facilitate the crystallization process by compensating the imbalance of hydrogen-bond donors and acceptors. NBO and QTAIM based calculations show that the hydrogen-bonding network of water molecules and hyper conjugative interactions play a vital role for stabilization of structure in the solid state. To our knowledge, presented here is the first illustration of any solvent cluster stabilizing the solid-state structure in a diazepine family. In addition, the crystal structure of flavone 3 hitherto not reported is also reported.

Long-afterglow light-storing type organic light-emitting material and preparation method thereof

The invention relates to the technical field of organic synthesis, particularly to a long-afterglow light-storing type organic light-emitting material and a preparation method thereof, and discloses apreparation method of a long-afterglow light-storing type organic light-emitting material with a structure as shown in a formula (I). According to the invention, the preparation method is cheap and easily-available in reaction raw materials, low in preparation cost, simple to operate, novel in reaction route, short in reaction time and synthetic route, mild in reaction condition, clean in reaction system and high in safety, and can obtain the long-afterglow light-storing type organic light-emitting material with the structure shown in the formula (I) with extremely high yield and selectivity;according to the preparation method, violent high-temperature conditions are avoided, highly toxic reagents and expensive metal catalysts are not used, and the preparation method is green and economical; and the preparation method has the advantages of simple post-treatment mode and less purification loss, greatly saves manpower, material resources and time, and can adapt to and meet the requirements of industrial production.

Design, synthesis and biological evaluation of substituted flavones and aurones as potential anti-influenza agents

We designed a series of substituted flavones and aurones as non-competitive H1N1 neuraminidase (NA) inhibitors and anti-influenza agents. The molecular docking studies showed that the designed flavones and aurones occupied 150-cavity and 430-cavity of H1N1-NA. We then synthesized these compounds and evaluated these for cytotoxicity, reduction in H1N1 virus yield, H1N1-NA inhibition and kinetics of inhibition. The virus yield reduction assay and H1N1-NA inhibition assay demonstrated that the compound 1f (4-methoxyflavone) had the lowest EC50 of 9.36 nM and IC50 of 8.74 μM respectively. Moreover, kinetic studies illustrated that compounds 1f and 2f had non-competitive inhibition mechanism.