19734-02-2

Basic information

• Product Name: 1-(2-hydroxyphenyl)pyrrolidin-2-one
• Synonyms: 1-(2-hydroxyphenyl)pyrrolidin-2-one;2-pyrrolidinone, 1-(2-hydroxyphenyl)-;1-(2-hydroxyphenyl)-2-pyrrolidinone;1-(2-hydroxyphenyl)-2-pyrrolidone;A1831/0077214;ZINC00069447
• CAS NO: 19734-02-2
• Molecular Formula: C₁₀H₁₁NO₂
• Molecular Weight: 177.19984
• Mol File: 19734-02-2.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-(2-hydroxyphenyl)pyrrolidin-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2-hydroxyphenyl)pyrrolidin-2-one(19734-02-2)
• EPA Substance Registry System: 1-(2-hydroxyphenyl)pyrrolidin-2-one(19734-02-2)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 19734-02-2(Hazardous Substances Data)

Usage

Derivation

Derived from the neurotransmitter gamma-aminobutyric acid (GABA)

Classification

Nootropic (smart drug)

Cognitive Function

Believed to enhance cognitive function, memory, and learning

Stimulating Effects

Thought to have stimulating and psychostimulant effects

Potential Applications

Improving focus and concentration

Therapeutic Applications

Studied for potential use in treating cognitive impairments and neurological disorders

Research Status

More research is needed to fully understand its mechanisms of action and potential risks.

Upstream product

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Downstream Products

• 23196-06-7 1-(2-methoxyphenyl)pyrrolidin-2-one 
• 857763-87-2 1-(2-methoxy-3-nitro-phenyl)-pyrrolidin-2-one 

Relevant articles and documents

METHOD FOR PRODUCING AN ARENE WITH AN AROMATIC C-N BOND ORTHO TO AN AROMATIC C-O BOND

A method for producing an arene with an aromatic C—N bond ortho to an aromatic C—O bond from a hydroxy arene comprising said aromatic C—O bond is provided. This method comprising the steps a) ortho-oxygenating the hydroxy arene to produce an ortho-quinone, b) condensating the ortho-quinone with a nitrogen nucleophile to generate a compound of Formula (IVa) or (IVb), and c) allowing 1,5-hydrogen atom shift of the compound of Formula (IVa) or (IVb), thereby producing arenes with a C—N bond ortho to a C—O bond of Formula (Va) and (Vb), respectively:

Synthesis of condensed heterocycles via cyclopropylimine rearrangement of cyclopropylazoles

Thermal cyclopropylimine rearrangement of cyclopropylazoles into condensed heterocycles and factors affecting the regioselectivity and conversion are reported. A method of conducting the reaction in the absence of solvents is developed. A series of 2-cyclopropylazoles, including novel examples, is synthesized and their transformations into the corresponding condensed heterocyclic compounds (2,3-dihydro-1H-pyrroles and 6,7-dihydro-5H-pyrrolo[2,1- b]thiazolium salts) are studied.

Synthesis of a new family of N-aryl lactams active on chemesthesis and taste

A new class of synthetic compounds with chemesthetic activity has been identified. They have been designed ex-novo by structural similarity with known cooling compounds such as menthol, icilin and cyclic ketoenamines. 19 new derivatives have been obtained

Selective syntheses of benzoxazoles and N-(2-hydroxyaryl)pyrrolidin-2-ones from the corresponding cyclopropyl amides with PPh3/CX4

Benzoxazoles 2 can be smoothly synthesized by treatment of starting materials of N-(2-hydroxyaryl) cyclopropyl amides 1 with PPh3/ CCl4 in acetonitrile in good yields. When PPh3/CBr 4/MS 4 ? was used in the reac