197368-44-8

Basic information

• Product Name: Co 102581
• Synonyms: Co 102581
• CAS NO: 197368-44-8
• Molecular Weight: 280.283
• Mol File: 197368-44-8.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: Co 102581(CAS DataBase Reference)
• NIST Chemistry Reference: Co 102581(197368-44-8)
• EPA Substance Registry System: Co 102581(197368-44-8)

Safety Data

• Hazardous Substances Data: 197368-44-8(Hazardous Substances Data)

Upstream product

• 326-59-0 benzo[1,3]dioxol-5-yl-acetic acid methyl ester 
• 98-88-4 benzoyl chloride 
• 717903-52-1 6-(trimethylsilyl)benzo[d][1,3]dioxol-5-yl triflate 
• 6006-82-2 3,4-methylenedioxyphenethyl alcohol 
• 2861-28-1 1,3-benzodioxole-5-acetic acid 
• 53616-33-4 5-phenyl-1,3-dioxolo[4,5-g]isochromane 
• 132813-86-6 2-Benzoyl-4,5-methylenedioxyphenylacetic acid 
• 132813-95-7 2-benzoyl-4,5-(methylenedioxy)-phenyl acetic acid methyl ester 

Downstream Products

• 250699-41-3 5-phenyl-7H-1,3-dioxolo[4,5-h][2,3]benzodiazepine-8(9H)-thione 
• 197368-51-7 7,8-Methylenedioxy-3-methyl-1-phenyl-3,5-dihydro-2,3-benzodiazepin-4(4H)-one 
• 862457-85-0 (2-methyl[1,3]dioxolan-2-ylmethyl)-(5-phenyl-7,9-dihydro-1,3-dioxa-6,7-diazacyclohepta[f]inden-8-ylidene)amine 
• 194730-09-1 5-phenyl-8-methyl-11H-1,3-dioxolo[4,5-h]imidazo[1,2-c][2,3]benzodiazepine 

Relevant articles and documents

Synthesis of 2,3-benzodiazepines and 2,3-benzodiazepin-4-ones from arynes and β-diketones

2,3-Benzodiazepines were synthesized by two-step or one-pot reactions from aryne precursors. Reaction of 2- (trimethylsilyl)aryl triflates with β-diketones in the presence of CsF gave ortho-substituted benzophenones. Treatment of benzophenones with hydrazine hydrate resulted in the formation of 2,3-benzodiazepines in moderate yields. Tofisopam, a well known anxiolytic, could be synthesized via C-C bond insertion of 3,4-dimethoxybenzyne with 2-ethyl-1-(3,4-dimethoxyphenyl)butane-1,3-dione, followed by the reaction with hydrazine hydrate in one-pot operation. 2,3-Benzodiazepin-4-ones were also synthesized by the reaction of β-keto esters with triflates in the presence of CsF, followed by the addition of hydrazine hydrate. Substituted isoquinolines were synthesized by the reaction of ortho-substituted benzophenones with ammonium hydroxide.

SUBSTITUTED 2,3-BENZODIAZEPIN-4-ONES AND THE USE THEREOF

The invention relates to substituted 2,3-benzodiazepin-4-ones which are antagonists or positive modulators of AMPA receptors, and the use thereof for treating, preventing or ameliorating neuronal loss associated with stroke, global and focal ischemia, CNS

SUBSTITUTED 2,3-BENZODIAZEPIN-4-ONES AND THE USE THEREOF

The invention relates to substituted 2,3-benzodiazepin-4-ones which are antagonists or positive modulators of AMPA receptors, and the use thereof for treating, preventing or ameliorating neuronal loss associated with stroke, global and focal ischemia, CNS trauma, hypoglycemia and surgery, as well as treating or ameliorating neurodegenerative diseases including Alzheimer's disease, amyotrophic lateral sclerosis, Huntington's disease, Parkinson's disease and Down's syndrome, treating, preventing or ameliorating the adverse consequences of the overstimulation of the excitatory amino acids, treating or ameliorating anxiety, psychosis, convulsions, chronic pain, glaucoma, CMV retinitis, urinary incontinence, muscular spasm and inducing anesthesia, as well as for treating or ameliorating the adverse consequences of excitatory amino acid deficiency such as schizophrenia, Alzheimer's disease and malnutrition and neural maldevelopment, and as cognition enhancers. The invention also is directed to the process for the preparation of the substituted 2,3-benzodiazepin-4-ones.