197378-18-0Relevant academic research and scientific papers
NOVEL BENZOTHIAZEPINE AND BENZOTHIEPINE COMPOUNDS
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Example P1, (2010/11/24)
A pharmaceutical useful as a therapeutic agent and a preventive agent for hyperlipemia, and a pharmaceutical useful as a therapeutic agent and a preventive agent for hepatic disorders associated with cholestasis, particularly, primary biliary cirrhosis an
Discovery of potent, nonsystemic apical sodium-codependent bile acid transporter inhibitors (part 2)
Huang, Horng-Chih,Tremont, Samuel J.,Lee, Len F.,Keller, Bradley T.,Carpenter, Andrew J.,Wang, Ching-Cheng,Banerjee, Shyamal C.,Both, Scott R.,Fletcher, Theresa,Garland, Danny J.,Huang, Wei,Jones, Claude,Koeller, Kevin J.,Kolodziej, Steve A.,Li, James,Manning, Robert E.,Mahoney, Matthew W.,Miller, Raymond E.,Mischke, Deborah A.,Rath, Nigam P.,Reinhard, Emily J.,Tollefson, Michael B.,Vernier, William F.,Wagner, Grace M.,Rapp, Steve R.,Beaudry, Judy,Glenn, Kevin,Regina, Karen,Schuh, Joe R.,Smith, Mark E.,Trivedi, Jay S.,Reitz, David B.
, p. 5853 - 5868 (2007/10/03)
In the preceding paper several compounds were reported as potent apical sodium-codependent bile acid transporter (ASBT) inhibitors. Since the primary site for active bile acid reabsorption is via ASBT, which is localized on the luminal surface of the dist
