197384-98-8Relevant academic research and scientific papers
Identification of orally-bioavailable antagonists of the TRPV4 ion-channel
Wei, Zhi-Liang,Nguyen, Margaret T.,O'Mahony, Donogh J.R.,Acevedo, Alejandra,Zipfel, Sheila,Zhang, Qingling,Liu, Luna,Dourado, Michelle,Chi, Candace,Yip, Victor,Defalco, Jeff,Gustafson, Amy,Emerling, Daniel E.,Kelly, Michael G.,Kincaid, John,Vincent, Fabien,Duncton, Matthew A.J.
, p. 4011 - 4015 (2015)
Abstract Antagonists of the TRPV4 receptor were identified using a focused screen, followed by a limited optimization program. The leading compounds obtained from this exercise, RN-1665 23 and RN-9893 26, showed moderate oral bioavailability when dosed to
METHOD FOR PRODUCING PENTAFLUOROSULFANYL BENZOIC ACID
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Paragraph 0073; 0074, (2014/10/28)
Provided is a simple, safe, and industrially practical method for producing a pentafluorosulfanylbenzoic acid. This method includes (A) a providing step of providing a trihalomethyl(pentafluorosulfanylbenzene) represented by general formula (1): where X i
AMIDOACETONITRILE COMPOUNDS AND PESTICIDAL COMPOSITION THEREOF
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Page/Page column 21, (2010/06/20)
The invention relates to compounds of the general formula (I) wherein the variable have the meanings as indicated in the claims, and optionally the enantiomers thereof. The active ingredients have advantageous pesticidal properties. They are especially su
ANTIPARASITIC AGENTS
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, (2008/12/07)
The present invention relates to compounds of the formula (I) or a tautomer or prodrug thereof, or a pharmaceutically acceptable salt of said compound, tautomer or prodrug, wherein: R1, R2, R3, R4 and R5 are each independently selected from H, halo, CN, CF3 and CONH2; compositions containing such compounds and the uses of such compounds as antiparasitic agents.
ANTIPARASITIC AGENTS
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Page/Page column 20, (2008/12/08)
The present invention relates to compounds of the formula (I) and pharmaceutically acceptable salts thereof, compositions containing such compounds and the uses of such compounds as antiparasitic agents.
