1046446-99-4

Upstream product

• 1779-49-3 Methyltriphenylphosphonium bromide 
• 401892-84-0 4-(pentafluoro- λ⁶-sulfanyl)benzaldehyde 
• 7486-35-3 tri-n-butyl(vinyl)tin 
• 286947-68-0 pentafluoro(4-iodophenyl)-λ⁶-sulfane 

Downstream Products

• 832-32-6 4-(pentafluoro-λ⁶-sulphanyl)benzoic acid 
• 1046446-37-0 N-{1-cyano-2-[4-cyano-2-fluoro-6-(trifluoromethyl)phenoxy]-1-methylethyl}-4-(pentafluorothio)benzamide 
• 1046820-92-1 N-{2-[2-chloro-5-cyano-3-(trifluoromethyl)phenoxy]-1-cyano-1-methylethyl}-4-(pentafluorothio)benzamide 
• 1046446-85-8 4-(2-cyano-2-{[4-(pentafluorothio)benzoyl]amino}propoxy)-3-(trifluoromethyl)-benzamide 
• 1046820-85-2 N-{1-cyano-2-[4-cyano-2-(trifluoromethyl)phenoxy]-1-methylethyl}-4-(pentafluorothio)benzamide 
• 1046820-83-0 N-{1-cyano-2-[5-cyano-2-(trifluoromethyl)phenoxy]-1-methylethyl}-4-(pentafluorothio)benzamide 
• 1046447-05-5 3-cyano-5-(2-cyano-2-{[4-(pentafluorothio)benzoyl]amino}propoxy)benzoic acid 
• 1046446-96-1 3-cyano-5-(2-cyano-2-{[4-(pentafluorothio)benzoyl]amino}propoxy)benzamide 
• 1046447-06-6 methyl-3-cyano-5-(2-cyano-2-{[4-(pentafluorothio)benzoyl]-amino}propoxy)benzoate 
• 1046820-90-9 N-[2-(2-chloro-5-cyanophenoxy)-1-cyano-1-methylethyl]-4-(pentafluorothio)benzamide 
• 1046446-46-1 N-[1-cyano-2-(2,4-dichlorophenoxy)-1-methylethyl]-4-(pentafluorothio)benzamide 
• 1046446-93-8 N-[1-cyano-2-(3-cyanophenoxy)-1-methylethyl]-4-(pentafluorothio)benzamide 
• 1046820-87-4 N-(1-cyano-2-hydroxy-1-methylethyl)-4-(pentafluorothio)benzamide 
• 197384-98-8 4-(pentafluoro-λ⁶-sulfanyl)benzoyl chloride 

Relevant academic research and scientific papers

Philicity of Acetonyl and Benzoyl Radicals: A Comparative Experimental and Computational Study

In this work, the reactivities of acetonyl and benzoyl radicals in aromatic substitution and addition reactions have been compared in an experimental and computational study. The results show that acetonyl is more electrophilic than benzoyl, which is rath

Synthesis and pKa values of 2-(3- and 4- pentafluorosulfanylphenyl)-2-fluorocyclopropylamines

Starting from 3- and 4-pentafluorosulfanylbenzaldehydes, a series of cis- and trans-2-aryl-2-fluorocyclopropylamines bearing an SF5 group in 3- or 4-position of the aryl ring were synthesized in 7 steps via the corresponding cyclopropanecarboxylic acids. While the pKa values of the carboxylic acids are very little depending on the stereochemistry at the cyclopropane ring and the regiochemistry of the SF5-substituents in the aryl ring, the pKa of the corresponding 2-fluorocyclopropylamines is strongly dependent on the stereochemistry at the three-membered ring due to hyperconjugative effects of the CF and the CN bonds. Again, the regiochemistry of SF5 substitution in the phenyl ring has almost no influence.

ANTIPARASITIC AGENTS

The present invention relates to compounds of the formula (I) and pharmaceutically acceptable salts thereof, compositions containing such compounds and the uses of such compounds as antiparasitic agents.

ANTIPARASITIC AGENTS

The present invention relates to compounds of the formula (I) or a tautomer or prodrug thereof, or a pharmaceutically acceptable salt of said compound, tautomer or prodrug, wherein: R1, R2, R3, R4 and R5 are each independently selected from H, halo, CN, CF3 and CONH2; compositions containing such compounds and the uses of such compounds as antiparasitic agents.