1974-32-9Relevant academic research and scientific papers
The development of a novel transforming growth factor-β (TGF-β) inhibitor that disrupts ligand-receptor interactions
Wu, Han,Sun, Yu,Wong, Wee Lin,Cui, Jiajia,Li, Jingyang,You, Xuefu,Yap, Lee Fah,Huang, Yu,Hong, Wei,Yang, Xinyi,Paterson, Ian C.,Wang, Hao
, (2020/01/21)
Transforming growth factor-β (TGF-β) plays an important role in regulating epithelial to mesenchymal transition (EMT) and the TGF-β signaling pathway is a potential target for therapeutic intervention in the development of many diseases, such as fibrosis and cancer. Most currently available inhibitors of TGF-β signaling function as TGF-β receptor I (TβR-I) kinase inhibitors, however, such kinase inhibitors often lack specificity. In the present study, we targeted the extracellular protein binding domain of the TGF-β receptor II (TβR-II) to interfere with the protein-protein interactions (PPIs) between TGF-β and its receptors. One compound, CJJ300, inhibited TGF-β signaling by disrupting the formation of the TGF-β-TβR-I-TβR-II signaling complex. Treatment of A549 cells with CJJ300 resulted in the inhibition of downstream signaling events such as the phosphorylation of key factors along the TGF-β pathway and the induction of EMT markers. Concomitant with these effects, CJJ300 significantly inhibited cell migration. The present study describes for the first time a designed molecule that can regulate TGF-β-induced signaling and EMT by interfering with the PPIs required for the formation of the TGF-β signaling complex. Therefore, CJJ300 can be an important lead compound with which to study TGF-β signaling and to design more potent TGF-β signaling antagonists.
Negative-working photosensitive poly(phenylene ether) based on poly(2,6-dimethyl-1,4-phenylene ether), a cross-linker, and a photoacid generator
Mizoguchi, Katsuhisa,Higashihara, Tomoya,Ueda, Mitsuru
experimental part, p. 2832 - 2839 (2011/10/09)
A novel benzyl cation type cross-linker, hex-1,6-ylenebis[oxy(2,4,6- tris(acetyloxymethyl)-3,5-dimethylbenzene)] (HOAD), that suppresses acid-catalyzed self-polycondensation has been developed. Furthermore, a negative-working, photosensitive poly(phenylen
MULTIMERIC MAGENTIC RESONANCE CONTRAST AGENTS
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Page/Page column 59, (2008/06/13)
The present invention relates to novel compounds of formula (I) and (II), compositions comprising compounds of formula (II) and their use as contrast agents in magnetic resonance (MR) imaging (MRI) and MR spectroscopy (MRS).
Triangular and tetrahedral array of silver(I) ions by a novel disk-shaped tridentate ligand: Dynamic control of coordination equilibrium of the silver(I) complexes
Hiraoka, Shuichi,Yi, Tao,Shiro, Motoo,Shionoya, Mitsuhiko
, p. 14510 - 14511 (2007/10/03)
A disk-shaped tridentate ligand 1 arranges silver(I) ions in a two-dimensional triangular and a three-dimensional tetrahedral fashion in the metal-ligand ratios, 3:2 and 1:1, respectively. The resulting sandwich-type (Ag312) and tetrahedral (Ag414) architectures are in a dynamic equilibrium in solution. Copyright
Self-assembly of 1,3,5-benzenetricarboxylic (trimesic) acid and its analogues
Kolotuchin, Sergei V.,Thiessen, Paul A.,Fenlon, Edward E.,Wilson, Scott R.,Loweth, Colin J.,Zimmerman, Steven C.
, p. 2537 - 2547 (2007/10/03)
A crystalline inclusion complex between 1,3,5-benzenetricarboxylic acid (trimesic acid, 1) and pyrene was grown from diethyl ether/ethanol and its structure was determined by X-ray analysis. Trialkyltrimesic acids 4b-4e were synthesized in seven steps fro
OXIDATION OF HEXAMETHYLBENZENE AND 2,3,4,5,6-PENTAMETHYLBENZYL CATION IN FLUOROSULFONIC ACID
Rudenko, A. P.,Zarubin, M. Ya.,Fedorova, E. M.
, p. 1609 - 1618 (2007/10/02)
The oxidation of hexamethylbenzene in HSO3F-PbO2 takes place with the participation of the 1-H+-1,2,3,4,5,6-hexamethylbenzenonium ion and the intermediate formation of the 2,3,4,5,6-pentamethylbenzyl cation, which is capable of entering into further oxidative transformations leading to substitution of the hydrogen atom in two and three methyl groups.The structure of the final products from the observed transformations were established, and a mechanism is proposed for their formation.
