19750-29-9 Usage
Uses
Used in Pharmaceutical Industry:
2-CHLORO-N-[4-(1H-INDOL-3-YL)-1,3-THIAZOL-2-YL]ACETAMIDE is used as a building block for the synthesis of new drug candidates due to its unique structure and potential biological activities. It may contribute to the development of novel therapeutic agents for various medical conditions.
Used in Agrochemical Industry:
2-CHLORO-N-[4-(1H-INDOL-3-YL)-1,3-THIAZOL-2-YL]ACETAMIDE is used as a chemical intermediate in the production of agrochemicals. Its potential applications in this field may include the development of new pesticides, herbicides, or other agricultural chemicals that can improve crop yield and protect plants from pests and diseases.
Used in Materials Science:
2-CHLORO-N-[4-(1H-INDOL-3-YL)-1,3-THIAZOL-2-YL]ACETAMIDE may also find applications in materials science, where its unique structure could be utilized in the development of new materials with specific properties. These materials could have potential uses in various industries, such as electronics, coatings, or advanced materials for specific applications.
Check Digit Verification of cas no
The CAS Registry Mumber 19750-29-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,9,7,5 and 0 respectively; the second part has 2 digits, 2 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 19750-29:
(7*1)+(6*9)+(5*7)+(4*5)+(3*0)+(2*2)+(1*9)=129
129 % 10 = 9
So 19750-29-9 is a valid CAS Registry Number.
19750-29-9Relevant academic research and scientific papers
Synthesis and evaluation of 5,6-disubstituted thiopyrimidine aryl aminothiazoles as inhibitors of the calcium-activated chloride channel TMEM16A/Ano1
Piechowicz, Katarzyna A.,Truong, Eric C.,Javed, Kashif M.,Chaney, Rachelle R.,Wu, Johnny Y.,Phuan, Puay W.,Verkman, Alan S.,Anderson, Marc O.
, p. 1362 - 1368 (2016/10/09)
Transmembrane protein 16A (TMEM16A), also called Ano1, is a Ca2+ activated Cl? channel expressed widely in mammalian epithelia, as well as in vascular smooth muscle and some tumors and electrically excitable cells. TMEM16A inhibitors have potential utility for treatment of disorders of epithelial fluid and mucus secretion, hypertension, some cancers and other diseases. 4-Aryl-2-amino thiazole T16Ainh-01 was previously identified by high-throughput screening. Here, a library of 47 compounds were prepared that explored the 5,6-disubstituted pyrimidine scaffold found in T16Ainh-01. TMEM16A inhibition activity was measured using fluorescence plate reader and short-circuit current assays. We found that very little structural variation of T16Ainh-01 was tolerated, with most compounds showing no activity at 10 μM. The most potent compound in the series, 9bo, which substitutes 4-methoxyphenyl in T16Ainh-01 with 2-thiophene, had IC50 ～1 μM for inhibition of TMEM16A chloride conductance.
