197507-55-4

Usage

Uses

Used in Pharmaceutical Industry:
8-Bromo-1,6-naphthyridine-2-carboxylic acid is used as a building block for the development of new drugs, leveraging its antimicrobial and antifungal properties to create effective treatments for various infections and diseases.
Used in Agrochemical Industry:
In the agrochemical sector, 8-Bromo-1,6-naphthyridine-2-carboxylic acid is utilized as an intermediate in the production of pesticides, contributing to the creation of innovative solutions for crop protection and disease control in agriculture.
Used in Organic Synthesis:
8-Bromo-1,6-naphthyridine-2-carboxylic acid is employed as an important reagent in the field of organic synthesis, where it is used in the preparation of diverse heterocyclic compounds with potential biological activities, expanding the scope of chemical research and development.
Used in Research and Development:
As a research tool, 8-Bromo-1,6-naphthyridine-2-carboxylic acid aids in the study of biological processes and disease mechanisms, providing insights that can lead to advancements in medical and biological sciences.

InChI:InChI=1/C9H5BrN2O2/c10-6-4-11-3-5-1-2-7(9(13)14)12-8(5)6/h1-4H,(H,13,14)

Upstream product

• 197507-59-8 1,6-naphthyridine-2-carboxylic acid 
• 116026-93-8 4--3-pyridinecarboxaldehyde 
• 42373-30-8 4-aminonicotinaldehyde 
• 98400-69-2 N-(4-pyridyl) t-butyl carbamate 

Downstream Products

• 197507-13-4 8-bromo-[1,6]naphthyridine-2-carboxylic acid (2-isopropoxybenzylamide) 
• 439798-42-2 8-bromo-[1,6]naphthyridine-2-carboxylic acid 2-hydroxy-benzylamide 
• 875514-20-8 8-bromo-[1,6]naphthyridine-2-carboxylic acid methyl ester 
• 1242446-47-4 8-(3-(trifluoromethyl)phenyl)-1,6-naphthyridine-2-carboxylic acid 
• 1611472-33-3 8-(4-chlorophenyl)-N-phenyl-1,6-naphthyridine-2-carboxamide 
• 1611472-34-4 8-(4-chlorophenyl)-N-(pyridin-3-yl)-1,6-naphthyridine-2-carboxamide 
• 1611472-35-5 8-(4-chlorophenyl)-N-(1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridine-2-carboxamide 
• 1611472-36-6 (8-(4-chlorophenyl)-1,6-naphthyridin-2-yl)(piperidin-1-yl)methanone 
• 1611472-37-7 (8-(4-chlorophenyl)-1,6-naphthyridin-2-yl)(morpholino)methanone 
• 1611472-38-8 tert-butyl 4-(8-(4-chlorophenyl)-1,6-naphthyridine-2-carbonyl)piperazine-1-carboxylate 
• 1611472-39-9 8-(4-chlorophenyl)-N-(piperidin-1-yl)-1,6-naphthyridine-2-carboxamide 
• 1611472-40-2 8-(4-chlorophenyl)-N-(tetrahydrofuran-3-yl)-1,6-naphthyridine-2-carboxamide 
• 1611472-41-3 (8-(4-chlorophenyl)-1,6-naphthyridin-2-yl)(piperazin-1-yl)methanone 
• 1611472-42-4 8-(4-chlorophenyl)-N-((2-methyl-5-oxopyrrolidin-2-yl)methyl)-1,6-naphthyridine-2-carboxamide 

Relevant academic research and scientific papers

SUBSTITUTED MONO- AND POLYAZANAPHTHALENE DERIVATIVES AND THEIR USE

Disclosed are compounds of formula (I) wherein A is CH or N, B is CR or N; and D is CR; R represents hydrogen, OH or NH2; R1 and R2, independently of each other, represent hydrogen, N(R3)2, halogen, cyano, nitro, R4-C1-C4alkyl, R4-C1-C4halogenoalkyl, OH, R4-C1-C4alkoxy, R4-C1-C4halogenoalkoxy, SH, R4-C1-C4alkythio, R4-C1-C4halogenoalkylthio; R3 represents, independently at each occurrence, hydrogen, R4-C1-C4alkyl or R4-C1-C4halogenoalkyl; R3a represents, independently at each occurrence, hydrogen or C1-C4 alkyl; R4 represents, independently at each occurrence, hydrogen, halogen, cyano, OH, SH, NH2, NH(CH3) or N(CH3)2; X represents a group of formula –E- or –E-F-, wherein E and F are different from each other and represent a group selected from –C(R3a)2-, -(C=O)-, -NR3a- and -O- and F is linked to Y, with the proviso that if X represents –E-F- one of E or F represents –C(R3a)2- or -(C=O)-; Y represents a group selected from C1-C6alkyl, mono- or bicyclic C3-C11cycloalkyl, which may be partially unsaturated, mono- or bicyclic 3 to 11-membered heterocycloalkyl, which may be partially unsaturated, a mono- or bicyclic group comprising at least one aryl or heteroaryl cycle, wherein said heterocycloalkyl group and said group comprising at least one heteroaryl cycle comprise one or more heteroatoms selected from nitrogen, oxygen and sulfur and said group Y is either unsubstituted or substituted by one or more substituents and comprises including its substituents one or more than one nitrogen atom having a lone electron pair; and Z represents a mono- or bicyclic group comprising at least one aryl or heteroaryl cycle, said heteroaryl cycle comprising one or more heteroatoms selected from nitrogen, oxygen and sulfur, which aryl or heteroaryl group is unsubstituted or substituted by one or more substituents; including tautomers of said compounds, mixtures of two tautomeric forms of said compounds, and pharmaceutically acceptable salts of said compounds, tautomers thereof or mixtures of two tautomeric forms thereof, preferably with the proviso that Y comprises one or more primary amino group -NH2, when X represents -(C=O)- or –(C=O)-NR3a-, wherein R3a represents hydrogen or C1-C4alkyl; which are useful for the treatment of proliferation disorders or diseases, such as cancer.

Design and synthesis of a potent macrocyclic 1,6-napthyridine anti-human cytomegalovirus (HCMV) inhibitors

A novel class of macrocyclic 1,6-napthyridines designed to adopt the presumed bioactive conformation of anti-HCMV acyclic 1,6-napthyridines are described. Both 14- and 15-membered macrocycles were shown to be highly potent against HCMV HSV-1 and HSV-2.