197514-04-8

Basic information

• Product Name: 4-chloro-2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)benzoic acid
• Synonyms: 4-chloro-2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)benzoic acid
• CAS NO: 197514-04-8
• Molecular Weight: 301.686
• Mol File: 197514-04-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-chloro-2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)benzoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 4-chloro-2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)benzoic acid(197514-04-8)
• EPA Substance Registry System: 4-chloro-2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)benzoic acid(197514-04-8)

Safety Data

• Hazardous Substances Data: 197514-04-8(Hazardous Substances Data)

Upstream product

• 85-44-9 phthalic anhydride 
• 89-77-0 2-Amino-4-chlorobenzoic acid 

Downstream Products

• 39061-72-8 2-acetyl-5-chloroaniline 
• 1379148-03-4 diethyl (3-chloro-6,11-dioxo-6H-isoindolo[2,1-a]indol-10b(11H)-yl)phosphonate 
• 1379148-02-3 diethyl 3-chloro-6-oxo-6H-isoindolo[2,1-a]indol-11-yl phosphate 
• 1379148-04-5 C₂₃H₂₈ClNO₉P₂ 
• 1379148-00-1 C₁₉H₁₇ClNO₆P 
• 1379148-01-2 C₂₅H₃₂ClNO₉P₂ 
• 1379147-89-3 4-chloro-2-(1,3-dioxoisoindolin-2-yl)benzoyl chloride 
• 2642-63-9 3',4'-dichloroacetophenone 
• 855929-69-0 acetic acid-(6-acetyl-3-chloro-2-nitro-anilide) 
• 96228-48-7 2-acetamido-4-chloro-5-nitroacetophenone 
• 857560-77-1 1-(2-amino-4-chloro-5-nitro-phenyl)-ethanone 
• 857560-79-3 1-(2-amino-4-chloro-3-nitro-phenyl)-ethanone 
• 103274-64-2 acetic acid-(2-acetyl-5-chloro-anilide) 
• 5465-65-6 4-chloro-3-nitroacetophenone 

Relevant articles and documents

A novel approach to isoindolo[2,1-a]indol-6-ones

A convenient route to isoindolo[2,1-a]indol-6-ones has been developed starting from the appropriate 2-(N-phthaloyl)benzoic acids. Formation of the acid chlorides with thionyl chloride followed by heating with triethyl phosphite in a suitable solvent resulted in a multistep reaction giving tetracyclic β-ketophosphonates that on reduction with sodium borohydride gave the required indolones in good overall yields. Analogous β-ketophosphonates were also prepared starting with N,N-(1,8-naphthaloyl)-2-aminobenzoic acid and 2-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)benzoic acids although of these only the naphthaloyl product could be reduced with sodium borohydride without cleaving the amide bond in the ring system.