19752-84-2Relevant articles and documents
Hydroxynitrile lyase catalysed synthesis of heterocyclic (R)- and (S)-cyanohydrins
Avi, Manuela,Fechter, Martin H.,Gruber, Karl,Belaj, Ferdinand,P?chlauer, Peter,Griengl, Herfried
, p. 10411 - 10418 (2004)
Heterocyclic saturated five- and six-membered ring ketones sometimes bearing a methyl substituent were reacted with HCN under enzyme catalysis using recombinant hydroxynitrile lyase from Hevea brasiliensis, as a rule (S)-selective, and Prunus amygdalus, (R)-selective. The resulting cyanohydrins were stereochemically characterised. The steric outcome of these transformations was interpreted by molecular modelling. The resulting cyanohydrins were stereochemically characterised and the mechanistic course of the transformations interpreted by molecular modelling.
Hydroboration of Prochiral Olefins with Chiral Lewis Base-Borane Complexes: Relationship to the Mechanism of Hydroboration
Narayana, Chatla,Periasamy, Mariappan
, p. 1857 - 1859 (1987)
Alcohols with up to 19percent enantiomeric excess were obtained on hydroboration/oxidation of representative prochiral olefins using N-isobornyl-N-methylaniline-borane or N-benzyl-N-isopropyl-α-methylbenzylamine-borane indicating that the Lewis base is present in the hydroboration transition state.
Substituted pyridine compound and its method and use thereof
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Paragraph 0599; 0600, (2018/06/21)
The invention relates to a novel substitutive pyridine compound, and a pharmaceutically acceptable salt and a pharmaceutical preparation of the substitutive pyridine compound for regulating the activity of protein kinases and regulating signal responses between cells or in the cells. Meanwhile, the invention further relates to a pharmaceutical composition containing the compound provided by the invention, and a method for treating high proliferative diseases of mammals, especially human with the pharmaceutical composition.
N-methyl-N-phenyl-5-oxa-1-azaspiro[2.5]oct-1-en-2-amine - Synthesis and reactions of a synthon for AN UNKNOWN α-AMINO ACID
Loepfe, Michael,Linden, Anthony,Heimgartner, Heinz
, p. 1267 - 1282 (2011/05/14)
The synthesis of the heterospirocyclic amino azirine N-methyl-N-phenyl-5- oxa-1-azaspiro[2.5]oct-1-en-2-amine (6a) was achieved from 3,4-dihydro-2H-pyrane (7) via N-methyl-N-phenyltetrahydropyran-3-thiocarboxamide (11). The reactions of 6a with thiobenzoic acid and Z-Phe-OH, respectively, leading to the corresponding 3-benzoylaminotetrahydropyran-3-thiocarboxamide (13) and the diastereoisomeric dipeptide amides (14), respectively, demonstrate that 6a is a valuable synthon for the hitherto unknown 3-aminotetrahydropyrane-3-carboxylic acid. The structure of 13 was established by X-Ray crystallography. The Japan Institute of Heterocyclic Chemistry.