23462-75-1

Basic information

• Product Name: 2H-PYRAN-3(4H)-ONE, DIHYDRO-
• Synonyms: DIHYDRO-PYRAN-3-ONE;2H-PYRAN-3(4H)-ONE, DIHYDRO-;5,6-Dihydro-2H-pyran-3(4H)-one;Tetrahydro-2H-pyran-3-one;2H-PYRAN-3(4H)-ONE;tetrahydro-2H-3-pyranone;2H-PYRAN-3(4H)-ONE, DIHYD...;oxan-3-one
• CAS NO: 23462-75-1
• Molecular Formula: C₅H₈O₂
• Molecular Weight: 100.12
• EINECS: 1312995-182-4
• Mol File: 23462-75-1.mol
• Article Data: 16

Chemical Properties

• Boiling Point: 176 °C at 760 mmHg
• Flash Point: 70.4 °C
• Appearance: /
• Density: 1.065 g/cm³
• Vapor Pressure: 1.12mmHg at 25°C
• Refractive Index: 1.44
• Storage Temp.: Inert atmosphere,Store in freezer, under -20°C
• CAS DataBase Reference: 2H-PYRAN-3(4H)-ONE, DIHYDRO-(CAS DataBase Reference)
• NIST Chemistry Reference: 2H-PYRAN-3(4H)-ONE, DIHYDRO-(23462-75-1)
• EPA Substance Registry System: 2H-PYRAN-3(4H)-ONE, DIHYDRO-(23462-75-1)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 23462-75-1(Hazardous Substances Data)

Usage

Uses

Dihydro-?2H-?pyran-?3(4H)?-?one is a general chemical reagent used in the synthesis of pharmaceuticals such as the preparation of tetrahydropyran-2-yl chromans, a highly selective beta-site amyloid precursor protein cleaving enzyme 1 (BACE) inhibitor.

InChI:InChI=1/C5H8O2/c6-5-2-1-3-7-4-5/h1-4H2

Upstream product

• 19752-84-2 Oxan-3-ol 
• 98166-23-5 2H-pyran-3(6H)-one 
• 82272-05-7 4-(3,4-dihydro-2H-pyran-5-yl)morpholine 
• 328-50-7 α-ketoglutaric acid 
• 1403495-64-6 3,3-dimethoxytetrahydro-2H-pyran 
• 4469-60-7 dimethyl 2,2-dimethoxypentanedioate 
• 110-87-2 3,4-dihydro-2H-pyran 
• 98166-29-1 2-(3-Propinyloxy)-acetaldehyddiethylacetal 
• 78870-52-7 (1SR,6RS)-3,7-dioxa-bicyclo[4.1.0]heptane 
• 67-56-1 methanol 
• 73819-79-1 <α-tetrahydropyrannyloxy>-2 tetrahydropyrone-3 (S*, R*) 
• 73819-79-1 <α-tetrahydropyrannyloxy>-2 tetrahydropyrone-3 (S*, S*) 

Downstream Products

• 94411-73-1 3,4-Dihydro-2H-pyrano<3,2-b>chinolin 
• 94411-72-0 3,4-Dihydro-1H-pyrano<3,4-b>chinolin 
• 94411-77-5 3,4-Dihydro-10-phenyl-2H-pyrano<3,2-b>chinolin 
• 857681-19-7 rac-3-(1-oxo-4-phenyl-2,8-diaza-spiro[4.5]dec-8-yl)-tetrahydro-pyran-4-carbonitrile 
• 229007-18-5 4-(N-methyl-N-(tetrahydropyran-3-yl)aminomethyl)aniline 
• 1190854-69-3 > N-(Cyclopropylmethyl)-3-[4-(ethoxymethyl)-2,6-dimethoxyphenyl]-6-methoxy-N-(tetrahydro-2H-pyran-3-yl)pyrazolo[5,1-b][1,3]thiazole-7-amine 
• 1190854-71-7 > 3-[4-(Ethoxymethyl)-2,6-dimethoxyphenyl]-6-methoxy-N-propyl-N-(tetrahydro-2H-pyran-3-yl)pyrazolo[5,1-b][1,3]thiazole-7-amine 
• 1190854-77-3 N-(cyclopropylmethyl)-3-[2,6-dimethoxy-4-(methoxymethyl)phenyl]-6-methoxy-N-(tetrahydro-2H-pyran-3-yl)pyrazolo[5,1-b][1,3]thiazole-7-amine 
• 848324-33-4 2-amino-4,7-dihydro-5H-thieno[2,3-c]pyran-3-carboxamide 
• 1260088-82-1 N-(5,6-dihydro-2H-pyran-3-yl)-N-(4-methoxybenzyl)-4-nitrobenzamide 
• 873397-34-3 racemic tetrahydropyran-3-carboxylic acid 
• 1305321-54-3 3-({2-[(benzyloxycarbonyl)amino]-3-phenylpropanoyl}-amino)tetrahydropyran-3-carboxylic acid 
• 1305321-47-4 N-methyl-N-phenyltetrahydropyran-3-carboxamide 
• 1305321-48-5 N-methyl-N-phenyltetrahydropyran-3-thiocarboxamide 

Relevant articles and documents

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Substituted pyridine compound and its method and use thereof

The invention relates to a novel substitutive pyridine compound, and a pharmaceutically acceptable salt and a pharmaceutical preparation of the substitutive pyridine compound for regulating the activity of protein kinases and regulating signal responses between cells or in the cells. Meanwhile, the invention further relates to a pharmaceutical composition containing the compound provided by the invention, and a method for treating high proliferative diseases of mammals, especially human with the pharmaceutical composition.

Synthesis of dihydro-2H-pyran-3(4H)-one

A practical synthetic procedure for the synthesis of dihydro-2H-pyran-3(4H) -one is reported. The method commenced from the readily available α-ketoglutaric acid and allowed preparation of the title compound in four steps in 31% overall yield. ARKAT-USA, Inc.