1977-07-7

Usage

Uses

Used in Pharmaceutical Industry:
11-(4-methyl-1-piperazinyl)-5H-dibenzo(b,e)(1,4)diazepine is used as a potential anti-anxiety or sedative medication due to its effects on the central nervous system. It is being studied for its potential to alleviate symptoms of anxiety and depression, offering a new option for the treatment of mental health conditions.
Used in Research and Development:
In the field of neuroscience and psychopharmacology, 11-(4-methyl-1-piperazinyl)-5H-dibenzo(b,e)(1,4)diazepine serves as a subject of research to better understand its pharmacological properties and mechanisms of action. This knowledge can contribute to the development of new therapeutic agents and strategies for managing mental health disorders.

InChI:InChI=1/C18H20N4/c1-21-10-12-22(13-11-21)18-14-6-2-3-7-15(14)19-16-8-4-5-9-17(16)20-18/h2-9,19H,10-13H2,1H3

Upstream product

• 5933-35-7 N-(2-nitrophenyl)anthranilic acid 
• 88-67-5 2-Iodobenzoic acid 
• 95-54-5 1,2-diamino-benzene 
• 1829-28-3 ethyl 2-iodobenzoate 
• 109-01-3 1-methyl-piperazine 
• 5814-41-5 5,10-dihydro-11H-dibenzo[b,e][1,4]-diazepin-11-one 

Relevant academic research and scientific papers

Synthesis and evaluation of antitumor activity of dibenzodiazepine derivatives

Abstract: A series of dibenzodiazepine 2-position derivatives, bearing N-methylpiperazine at the C-11 position, were prepared by using a concise approach. Their inhibitory activities of tumor cell proliferation in vitro were tested in five cell lines, including breast cancer cell BCAP37, gastric cancer cell SGC7901, liver cancer cell HepG2, cervical cancer cell HeLa and acute promyelocytic leukemia cell HL-60. Several compounds showed efficient tumor activity with IC50 values down to 0.30?μM. These compounds are expected to be a new class of potential anticancer lead compounds. Graphic abstract: [Figure not available: see fulltext.]

Direct Reductive Cyclocondensation of the Nitro Group with the Amido Group: Key Role of the Iminophosphorane Intermediate in the Synthesis of 1,4-Dibenzodiazepine Derivatives

A class of dialkylamino-substituted dibenzodiazepines and their hetero analogues was synthesized by the intramolecular aza-Wittig condensation of the amido group with iminophosphoranes. The one-pot, two-step procedure includes reductive synthesis of the intermediate iminophosphoranes from the corresponding nitroamides and tributylphosphine.

Dibenzozepine compound and preparation method and application thereof

The invention discloses a dibenzozepine compound and a preparation method and application thereof. The structure of the dibenzozepine compound is as shown in the general formula 1 or general formula 2, wherein R1 is selected from methyl, hydrogen, chlorin

PESTICIDAL DIBENZO(HETERO)AZEPINE DERIVATIVES

Use of compounds of formula (I): wherein X is S, O, S=O, SO2, NRa, or CRbRc;R1,R2 are halogen, OH, SH, NH2, CN, NO2, alkyl, alkoxy, alkylamino, dialkylamino, alkylthio