197792-52-2

Usage

Uses

Used in Organic Synthesis:
Tert-butyl 2-(3-bromophenyl)acetate is utilized as a building block in organic synthesis for the creation of various compounds. Its unique structural features make it a valuable intermediate in the synthesis of complex organic molecules.
Used in Pharmaceutical Research:
In the pharmaceutical industry, tert-butyl 2-(3-bromophenyl)acetate is employed as a key component in the development of new drugs. Its structural properties allow for the design of molecules with specific biological activities, contributing to the advancement of medicinal chemistry.
Safety Considerations:
It is crucial to handle tert-butyl 2-(3-bromophenyl)acetate with care and adhere to proper safety protocols during its use in research and industrial applications to ensure the safety of personnel and the environment.

Upstream product

• 1878-67-7 3-Bromophenylacetic acid 
• 24424-99-5 di-tert-butyl dicarbonate 
• 75-65-0 tert-butyl alcohol 
• 1694-31-1 tert-butyl acetoacetate 
• 591-18-4 1-Bromo-3-iodobenzene 

Downstream Products

• 945399-11-1 [3-(4-oxopiperidin-1-yl)phenyl]acetic acid tert-butyl ester 
• 1265219-87-1 2-(3'-vinylphenyl)-acetic acid tert-butyl ester 

Relevant academic research and scientific papers

Catalytic Asymmetric Darzens-Type Epoxidation of Diazoesters: Highly Enantioselective Synthesis of Trisubstituted Epoxides

Highly enantioselective Darzens-type epoxidation of diazoesters with glyoxal derivatives was accomplished using a chiral boron–Lewis acid catalyst, which facilitated asymmetric synthesis of trisubstituted α,β-epoxy esters. In the presence of a chiral oxazaborolidinium ion catalyst, the reaction proceeded in high yield (up to 99 %) with excellent enantio- and diastereoselectivity (up to >99 % ee and >20:1 dr, respectively). The synthetic potential of this method was illustrated by conversion of the products to various compounds such as epoxy γ-butyrolactone, tertiary β-hydroxy ketone and epoxy diester.

Cu(I)/chiral bisoxazoline-catalyzed enantioselective sommelet-hauser rearrangement of sulfonium ylides

Catalytic asymmetric thia-Sommelet-Hauser rearrangement of sulfonium ylides remains a great challenge due to its multistep reaction mechanism involving metal carbene formation, proton transfer, and [2,3]-sigmatropic rearrangement. In particular, the key problem of such reactions is the differentiation of the enantiotopic lone pair electrons of sulfur, which generates the sulfonium ylide intermediate bearing chirality on the sulfur atom. With a modified chiral bisoxazoline ligand, we developed a Cu(I)- catalyzed asymmetric thia-Sommelet-Hauser rearrangement with good to excellent enantioselectivities. Mechanistic studies provide insights into the details of the reaction mechanism.

AROMATIC SULFONAMIDE DERIVATIVES

Substituted aromatic sulfonamides of formula (I) pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease.

Copper-catalyzed coupling of aryl iodides and tert-butyl keto esters: Efficient access to α-aryl ketones and α-arylacetic acid tert-butyl esters

CuI/trans-4-hydroxy-l-proline catalyzed coupling of aryl iodides with tert-butyl keto esters proceeded smoothly at 40 °C in DMF, providing α-aryl ketones after acid-promoted deprotection and decarboxylation of tert-butyl ester group. While CuI/2-picolinic acid catalyzed coupling of aryl iodides with tert-butyl acetoacetate at 70 °C in dioxane delivered α-arylacetic acid tert-butyl esters upon spontaneous deacylation. A wide range of functional groups, such as acetyl, methoxy, nitrile, nitro, bromo, and chloro were compatible with the reaction conditions.

Preparation of 16β-estradiol derivative libraries as bisubstrate inhibitors of 17β-hydroxysteroid dehydrogenase type 1 using the multidetachable sulfamate linker

Combinatorial chemistry is a powerful tool used to rapidly generate a large number of potentially biologically active compounds. In our goal to develop bisubstrate inhibitors of 17β-hydroxysteroid dehydrogenase type 1 (17β-HSD1) that interact with both th

SPIRO IMIDAZOLE DERIVATIVES AS PPAR MODULATORS

The invention provides compounds (Ia), (Ib) and (Ic), pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with the activity of the Peroxisome Proliferator-Activated

Biaryl compounds useful as anticancer agents

The present invention relates to compounds of formula I and to pharmaceutically acceptable salts, hydrates and prodrugs thereof, wherein R1, R2, R3, R4, R5, R10, R11, b, m, n, p