1978-06-9 Usage
General Description
2,3-Bis(trifluoromethyl)nitrobenzene is a chemical compound with the formula C7H3F6NO2. It is a nitroaromatic compound containing two trifluoromethyl groups attached to the 2 and 3 positions of the benzene ring. 2,3-BIS(TRIFLUOROMETHYL)NITROBENZENE is primarily used as a building block in the synthesis of various organic compounds, including pharmaceuticals, agrochemicals, and materials. It is known for its strong electron-withdrawing properties, making it a valuable reagent in organic chemistry. Additionally, the trifluoromethyl groups provide this compound with unique physical and chemical properties, making it useful in a wide range of applications. However, it is important to handle this compound with care, as it is considered hazardous and may cause irritation to the skin and eyes.
Check Digit Verification of cas no
The CAS Registry Mumber 1978-06-9 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,9,7 and 8 respectively; the second part has 2 digits, 0 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 1978-06:
(6*1)+(5*9)+(4*7)+(3*8)+(2*0)+(1*6)=109
109 % 10 = 9
So 1978-06-9 is a valid CAS Registry Number.
InChI:InChI=1/C8H3F6NO2/c9-7(10,11)4-2-1-3-5(15(16)17)6(4)8(12,13)14/h1-3H
1978-06-9Relevant articles and documents
Structure-activity relationships of antitubercular salicylanilides consistent with disruption of the proton gradient via proton shuttling
Lee, Ill-Young,Gruber, Todd D.,Samuels, Amanda,Yun, Minhan,Nam, Bora,Kang, Minseo,Crowley, Kathryn,Winterroth, Benjamin,Boshoff, Helena I.,Barry III, Clifton E.
, p. 114 - 126 (2013/02/22)
A series of salicylanilides was synthesized based on a high-throughput screening hit against Mycobacterium tuberculosis. A free phenolic hydroxyl on the salicylic acid moeity is required for activity, and the structure-activity relationship of the aniline ring is largely driven by the presence of electron withdrawing groups. We synthesized 94 analogs exploring substitutions of both rings and the linker region in this series and we have identified multiple compounds with low micromolar potency. Unfortunately, cytotoxicity in a murine macrophage cell line trends with antimicrobial activity, suggesting a similar mechanism of action. We propose that salicylanilides function as proton shuttles that kill cells by destroying the cellular proton gradient, limiting their utility as potential therapeutics.
