655-20-9

Usage

Uses

Used in Pharmaceutical Industry:
2-Fluorothioanisole is used as an intermediate in the synthesis of various pharmaceutical compounds for its ability to contribute to the development of new drugs and enhance their properties.
Used in Agrochemical Industry:
In the agrochemical sector, 2-Fluorothioanisole serves as a precursor in the production of agrochemicals, aiding in the creation of effective pest control agents and other agricultural products.
Used in Organic Synthesis:
As a reagent in organic synthesis, 2-Fluorothioanisole is utilized for its capacity to participate in various chemical reactions, facilitating the synthesis of complex organic molecules.
Used in Food Industry:
2-Fluorothioanisole is used as a flavoring agent in the food industry, where it imparts specific fruity notes to food products, enhancing their taste and appeal to consumers.

InChI:InChI=1/C7H7FS/c1-9-7-5-3-2-4-6(7)8/h2-5H,1H3

Upstream product

• 1072-85-1 o-fluorobromobenzene 
• 74-88-4 methyl iodide 
• 19614-16-5 2-bromo-1-(methylsulfanyl)benzene 
• 75-18-3 dimethylsulfide 
• 2557-78-0 2-fluorothiophenol 
• 624-92-0 Dimethyldisulphide 
• 367-11-3 ortho-difluorobenzene 
• 131049-54-2 o-potassiofluorobenzene 
• 348-52-7 1-Fluoro-2-iodobenzene 
• 462-06-6 fluorobenzene 
• 137092-16-1 2-Fluoro-benzenediazonium; hydrogen sulfate 
• 77-78-1 dimethyl sulfate 
• 137092-19-4 Dithiopivalinsaeure-2-fluorphenylester 

Downstream Products

• 126799-56-2 1-Benzyl-4-(2-(methylthio)phenoxy)piperidine 
• 705-02-2 o-Fluorophenylthioglycolic acid 
• 1978-16-1 1-fluoro-2-(trifluoromethylsulfanyl)benzene 
• 252555-43-4 1-(Ethylthio)-2-fluorobenzene 
• 130922-30-4 (R)-1-fluoro-2-(methylsulfinyl)benzene 
• 777094-91-4 (S)-2-fluorophenyl methyl sulfoxide 
• 2358-41-0 1-fluoro-2-[(trifluoromethyl)sulfonyl]benzene 
• 1402586-33-7 2-(3-fluoro-4-(methylthio)phenyl)-2-oxoacetic acid 
• 259543-76-5 2-(3-fluoro-4-(methylthio)phenyl)acetic acid 
• 1402586-34-8 2-(3-fluoro-4-(methylthio)phenyl)propanoic acid 
• 1402586-35-9 methyl 2-(3-fluoro-4-(methylthio)phenyl)propanoate 
• 1402586-36-0 methyl 2-(3-fluoro-4-(methylsulfonyl)phenyl)propanoate 
• 1402586-37-1 2-(3-fluoro-4-(methylsulfonyl)phenyl)propanoic acid 
• 1255040-87-9 N-[[5-tert-butyl-2-(3-chlorophenyl)-2H-pyrazol-3-yl]methyl]-2-(3-fluoro-4-methylsulfonylphenyl)propionamide 

Relevant academic research and scientific papers

t-BuOK-promoted methylthiolation of aryl fluorides with dimethyldisulfide under transition-metal-free and mild conditions

In the presence of potassium tert-butoxide (t-BuOK), the cross-coupling reaction between aryl fluorides and dimethyldisulfide was developed. A series of aryl methyl sulfides were obtained in moderate to good yields under transition-metal-free and mild conditions.

Copper-Catalyzed Methylthiolation of Aryl Iodides and Bromides with Dimethyl Disulfide in Water

An efficient route to aryl methyl sulfides through the copper-catalyzed coupling reaction of aryl iodides or bromides with dimethyl disulfide in water is described. Electron-donating and electron-withdrawing functional groups in the substrates were tolerated, and the corresponding products were obtained in moderate to good yields.

NOVEL OXADIAZOLES

The present invention relates to novel oxadiazoles of Formula I, wherein, R1, L1, A, L2 and R10 are as defined in the detailed description.

SUBSTITUTED PYRAZOLYL-BASED CARBOXAMIDE AND UREA DERIVATIVES BEARING A PHENYL MOIETY SUBSTITUTED WITH AN SO2-CONTAINING GROUP AS VANILLOID RECEPTOR LIGANDS

The invention relates to substituted pyrazolyl-based carboxamide and urea derivatives bearing a phenyl moiety substituted with a S02-containing group as vanilloid receptor ligands, to pharmaceutical compositions containing these compounds and also to these compounds for use in the treatment and/or prophylaxis of pain and further diseases and/or disorders.

Efficient synthesis of aryl fluorides

Chemical Equation Presented Creating C-F bonds: A novel electrophilic fluorination of aryl and heteroaryl Crignard reagents has been discovered and was used for the efficient synthesis of various aryl fluoride derivatives (see picture; THF = tetrahydrofuran).

Electroreduction of Organic Compounds, 19. Formation of Benzoanellated Sulfur Heterocycles by Intramolecular Cathodic Cyclization of Dithiocarboxylic Esters

Cathodic reduction of aryl (3) and benzyl (5) dithiopivaloates and related dithioesters with leaving groups at the benzene ring or a side chain yield the sulfur heterocycles 23, 30 - 32, and 34 depending on the nature of the starting material and the reaction conditions.In the case of the α-oxo-dithioester 22, thioindigo (44) is formed. - The corresponding thioamides 14, 16, and 18 show a strong tendency to reductive dehalogenation but the S,N-heterocycles 38 and 39 are also formed in minor amounts. - The formation of the rearranged products 29 - 32, and 34 isdiscussed in terms of C,S-splitting in the primarily formed radical anion and subsequent C,C-coupling of the fragments and follow-up reactions.Key Words: Dithiopivaloates, S-aryl, S-benzyl / Electroreduction

Generation of ortho-Potassiofluorobenzene and its Functionalization

A number of ortho-substituted fluorobenzenes are readily accessible by treating fluorobenzene at -100 deg C with 1:1 molar mixture of potassium tert-butoxide and n-butyllithium in tetrahydrofuran and hexane, and subsequently adding an electrophilic reagent.

POTENTIAL ANTIDEPRESSANTS: 4-(THIOARYLOXY)PIPERIDINES

Nucleophilic substitution reactions of a series of thio-substituted fluoroarenes with 1-methyl-4-piperidinol, 1-benzyl-4-piperidinol, and 1-methyl-4-phenyl-4-piperidinol in the presence sodium hydride in dimethylformamide gave the title compounds V-XI and XIII.The salts of these bases were pharmacologically tested and salts of compounds V, XI, and XIII showed in behavioural tests properties which are indicative of antidepressant activity.

Electroreduction of Organic Compounds, 13. - Coelectroreduction of Methyl Dithiocarboxylates with Halogenoarenes

Coelectroreduction of methyl dithiopivalate (1) or dithiobenzoate (11) with a monohalogenobenzene does not result in any characteristic products.However, the aryl methyl dithioacetals 7 and 8 are formed on cathodic reduction of 1 in the presence of the o-dihalogenobenzenes 4 and 5, respectively. - An SNAr mechanism is proposed, which is also in accordance with the formation of 2-bromobenzenethiolate (9) from 1 and 4 or 5.