1978-33-2 Usage
General Description
2-Fluoro-3-methylaniline is an organic compound with the chemical formula C?H?FN, and is classified as a substituted aniline. It is a colorless to pale yellow liquid with a mildly aromatic odor, and is used primarily as an intermediate in the synthesis of pharmaceuticals and agrochemicals. Its chemical structure consists of a fluorine atom attached to the second carbon of a benzene ring, and a methyl group attached to the third carbon. 2-Fluoro-3-methylaniline is considered to be slightly toxic and may cause skin and eye irritation, and proper handling and storage precautions should be taken when working with this chemical.
Check Digit Verification of cas no
The CAS Registry Mumber 1978-33-2 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,9,7 and 8 respectively; the second part has 2 digits, 3 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 1978-33:
(6*1)+(5*9)+(4*7)+(3*8)+(2*3)+(1*3)=112
112 % 10 = 2
So 1978-33-2 is a valid CAS Registry Number.
InChI:InChI=1/C7H8FN/c1-5-3-2-4-6(9)7(5)8/h2-4H,9H2,1H3
1978-33-2Relevant articles and documents
Industrial Cunninghamia lanceolata carbon supported FeO(OH) nanoparticles-catalyzed hydrogenation of nitroarenes
Fu, Lihua,Li, Dingzhong,Lu, Hao,Qiu, Renhua,Sun, Tulai,Xing, Chen,Yang, Tianbao
, (2022/01/11)
The development of green and efficient methods for hydrogenation of nitroarenes is still highly demanding in organic synthesis. Herein, we report an industrial Cunninghamia lanceolata carbon supported FeO(OH) nanoparticles process for the synthesis of aryl amines with good yields via hydrogenation of nitroarenes. Nine key anti-cancer drug intermediates were successfully achieved with protocol. And Osimertinib intermediate 4m can be smoothly synthesized at a 2.67 kg-scale with >99.5% HPLC purity. This protocol features cheap carbon source, highly catalytic activity, simple operation, kilogram-scalable and recyclable catalysts (eight times without observable losing activity).
