19788-56-8

Usage

Uses

Used in Pharmaceutical Industry:
α-(Benzoyloxy)-4-chlorobenzeneacetonitrile is used as an intermediate in the synthesis of pharmaceutical drugs. Its unique structure allows for the development of new drug candidates with potential therapeutic applications.
Used in Organic Chemistry Research:
In the field of organic chemistry, α-(Benzoyloxy)-4-chlorobenzeneacetonitrile is employed as a reagent in various chemical reactions. Its versatility in forming different chemical bonds and participating in reactions makes it a valuable tool for researchers in exploring new chemical pathways and synthesizing novel compounds.
Used in Laboratory Settings:
α-(Benzoyloxy)-4-chlorobenzeneacetonitrile is used in laboratory settings for educational and research purposes. Its properties and reactivity are studied to understand its behavior in different chemical environments and to develop safer and more efficient methods for its synthesis and use.

Upstream product

• 151-50-8 potassium cyanide 
• 104-88-1 4-chlorobenzaldehyde 
• 98-88-4 benzoyl chloride 
• 613-90-1 benzoyl cyanide 
• 13014-48-7 4-chlorobenzoyl cyanide 
• 100-52-7 benzaldehyde 
• 116943-91-0 5-benzoyl-4,5-dihydro-6-methyl-1-phenyl-1H-pyrazolo<3,4-d>pyrimidine-4-carbonitrile 

Downstream Products

• 99933-49-0 Benzoic acid (4-chloro-phenyl)-cyano-quinazolin-4-yl-methyl ester 
• 89549-81-5 Benzoic acid (4-chloro-phenyl)-cyano-(1-phenyl-1H-pyrazolo[3,4-d]pyrimidin-4-yl)-methyl ester 
• 59563-90-5 (4-chloro-phenyl)-(1-phenyl-1H-pyrazolo[3,4-d]pyrimidin-4-yl)-methanone 
• 87412-79-1 1-phenyl-4-(p-chlorophenyl)pyrazolo<3,4-d>pyrimidine 

Relevant academic research and scientific papers

Synthesis of Imidazoles and Oxazoles via a Palladium-Catalyzed Decarboxylative Addition/Cyclization Reaction Sequence of Aromatic Carboxylic Acids with Functionalized Aliphatic Nitriles

We herein report an efficient approach for the assembly of multiply substituted imidazoles and oxazoles in a single-step manner. These transformations are based on a decarboxylation addition and annulation of readily accessible aromatic carboxylic acids a

Palladium-catalyzed C-H activation of simple arenes and cascade reaction with nitriles: access to 2,4,5-trisubstituted oxazoles

An efficient and straightforward protocol for the assembly of the pharmaceutically and biologically valuable oxazole skeleton is achieved for the first time from readily available simple arenes and functionalized aliphatic nitriles. This transformation in

Divergent Palladium-Catalyzed Tandem Reaction of Cyanomethyl Benzoates with Arylboronic Acids: Synthesis of Oxazoles and Isocoumarins

A palladium-catalyzed tandem reaction of cyanomethyl benzoates with arylboronic acids has been achieved. Substitution at the 2-position of cyanomethyl benzoates was found to be crucial for the selective synthesis of oxazoles and isocoumarins. Cyanomethyl

Solvent-free synthesis of cyanohydrin derivatives catalysed by triethylamine

A very simple one-step environmentally friendly procedure for the synthesis of O-substituted cyanohydrins from aldehydes and ketones, in the absence of solvent, employing minimum amounts of the corresponding cyanides has been optimised. Aldehydes react more rapidly than ketones using triethylamine as catalyst offering in both cases almost quantitative yields of the corresponding O-trimethylsilyl, O-methoxycarbonyl, O-benzoyl and O-acetyl cyanohydrins. Georg Thieme Verlag Stuttgart.

A convenient and improved method for the preparation of cyanohydrin esters from acyl cyanides and aldehydes

Various kinds of cyanohydrin esters can be obtained in good to excellent yields from aldehydes by treatment with acyl cyanides in a heterogeneous mixture of aqueous potassium carbonate and acetonitrile.

DABCO-Mediated Synthesis and Biological Activity of Cyanihydrin Esters

Cyanohydrin esters 1-31 have been prepared from α-ketonitriles and aldehydes using DABCO (1,4-diazabicyclooctane) as nucleophilic acylation catalyst.The modofied piperonal 8 was found to inhibit the formation of thromboxane synthetase.

Studies on Pyrazolopyrimidine Derivatives. XIII. Aryl Migration of 4-Aroyl-1H-pyrazolopyrimidines to 4-Aryl-4,5-dihydro-1H-pyrazolopyrimidine-4-carboxylic Acids

When a mixture of 4-aroyl-1-phenyl-1H-pyrazolopyrimidines (3) and sodium hydroxide in dimethyl sulfoxide (DMSO) was stirred for 1 h at room temperature, migration of the aryl group to the 4-position occurred, i.e., the benzilic acid rearrangement,