197914-93-5Relevant academic research and scientific papers
3-substituted-4-hydroxy-7-chromanylacetic acid derivatives as antagonists of the leukotriene B4 (LTB4) receptor
Reiter, Lawrence A.,Melvin Jr., Lawrence S.,Crean, Geraldine L.,Showell, Henry J.,Koch, Kevin,Biggers, Michael S.,Cheng, John B.,Breslow, Robbin,Conklyn, Maryrose J.,Farrell, Cathy A.,Hada, William A.,Laird, Ellen R.,Martin, John J.,Miller, G. Todd,Pillar, Joanne S.
, p. 2307 - 2312 (1997)
The SAR of a series of 7-chromanylacetic acids has been investigated with the aim of identifying potent and selective LTB4 receptor antagonists. We found optimal activity in derivatives with α,α-disubstitution on the acetic acid and a C-4 hydroxy group and a C-3 lipophilic group on the chromane ring. CP-105696 (43), which contains a 4-phenylbenzyl C-3 substituent, was selected for development.
