Bioorganic and Medicinal Chemistry Letters p. 2307 - 2312 (1997)
Update date:2022-07-29
Topics:
Reiter, Lawrence A.
Melvin Jr., Lawrence S.
Crean, Geraldine L.
Showell, Henry J.
Koch, Kevin
Biggers, Michael S.
Cheng, John B.
Breslow, Robbin
Conklyn, Maryrose J.
Farrell, Cathy A.
Hada, William A.
Laird, Ellen R.
Martin, John J.
Miller, G. Todd
Pillar, Joanne S.
The SAR of a series of 7-chromanylacetic acids has been investigated with the aim of identifying potent and selective LTB4 receptor antagonists. We found optimal activity in derivatives with α,α-disubstitution on the acetic acid and a C-4 hydroxy group and a C-3 lipophilic group on the chromane ring. CP-105696 (43), which contains a 4-phenylbenzyl C-3 substituent, was selected for development.
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Doi:10.1016/S0040-4020(97)10046-1
(1997)Doi:10.1007/BF00601117
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(1997)Doi:10.1021/om9707026
(1997)Doi:10.1016/S0040-4039(97)10283-0
(1997)Doi:10.1016/S0022-328X(99)00029-7
(1999)
