3-substituted-4-hydroxy-7-chromanylacetic acid derivatives as antagonists of the leukotriene B4 (LTB4) receptor

Article abstract of DOI:10.1016/S0960-894X(97)00414-9

The SAR of a series of 7-chromanylacetic acids has been investigated with the aim of identifying potent and selective LTB₄ receptor antagonists. We found optimal activity in derivatives with α,α-disubstitution on the acetic acid and a C-4 hydroxy group and a C-3 lipophilic group on the chromane ring. CP-105696 (43), which contains a 4-phenylbenzyl C-3 substituent, was selected for development.