19797-32-1

Basic information

• Product Name: Benzenesulfonamide,3,5-dichloro-
• Synonyms: 3,5-Dichlorobenzenesulfonamide
• CAS NO: 19797-32-1
• Molecular Formula: C₆H₅Cl₂NO₂S
• Molecular Weight: 226.0804
• Product Categories: Sulfur Compounds;Benzenes;Fluorobenzene;Benzene derivates;Organic Building Blocks;Sulfonamides/Sulfinamides
• Mol File: 19797-32-1.mol
• Article Data: 4

Chemical Properties

• Melting Point: 161-165℃
• Boiling Point: 395.598 °C at 760 mmHg
• Flash Point: 193.051 °C
• Appearance: /
• Density: 1.589 g/cm³
• Vapor Pressure: 1.82E-06mmHg at 25°C
• Refractive Index: 1.602
• PKA: 9.54±0.60(Predicted)
• CAS DataBase Reference: Benzenesulfonamide,3,5-dichloro-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenesulfonamide,3,5-dichloro-(19797-32-1)
• EPA Substance Registry System: Benzenesulfonamide,3,5-dichloro-(19797-32-1)

Safety Data

• Hazard Codes: Xi:Irritant
• Safety Statements: S22:; S24/25:
• WGK Germany: 3
• RTECS: DB1670000
• Hazardous Substances Data: 19797-32-1(Hazardous Substances Data)

Usage

General Description

Benzenesulfonamide, 3,5-dichloro- is a chemical compound with the molecular formula C6H5Cl2NO2S. It is a derivative of sulfonamide, which is widely used in medicine as an antibiotic. This particular compound has two chlorine atoms attached to the benzene ring, giving it its specific chemical and physical properties. It is also used as a reaction intermediate in organic synthesis and in the production of pharmaceuticals. Additionally, it has applications in the manufacturing of dyes and pigments. However, it is important to handle this chemical with care, as it can be toxic to aquatic organisms and may cause skin irritation and respiratory issues in humans if proper safety precautions are not taken.

InChI:InChI=1/C6H5Cl2NO2S/c7-4-1-5(8)3-6(2-4)12(9,10)11/h1-3H,(H2,9,10,11)

Upstream product

• 705-21-5 3,5-dichlorobenzensulfonyl chloride 

Downstream Products

• 84615-17-8 C₆H₄Cl₂N₂O₄S 
• 817200-64-9 1,1-dimethylethyl[(3,5-dichlorophenyl)sulfonyl]carbamate 
• 1263313-42-3 3,5-dichloro-N-[2-(2,2-dimethyl-propionyl)-phenyl]-benzenesulfonamide 
• 1254305-47-9 C₁₅H₇Cl₃F₃N₃O₃S 
• 1131395-12-4 3,5-dichloro-N-[6-(5-methyl-[1,2,4]oxadiazol-3-yl)-naphthalen-1-yl]-phenylsulphonamide 
• 1057257-36-9 C₂₈H₂₀Cl₂N₂O₄S 
• 19797-38-7 N-phenyl-3,5-dichlorobenzenesulfonamide 
• 133514-50-8 C₁₂H₈Cl₃NO₂S 
• 1173838-90-8 N-(4-fluorophenyl)-3,5-dichlorobenzenesulfonamide 
• 1138722-85-6 C₂₅H₂₂Cl₄N₂O₄S 
• 1057256-50-4 3,5-Dichloro-N-[2-(1H-indol-4-yloxy)-acetyl]-benzenesulfonamide 
• 1044266-22-9 C₁₂H₇Cl₂F₃N₂O₂S 
• 19797-35-4 4-(3,5-dichloro-benzenesulfonyl)-morpholine 

Relevant articles and documents

Cu(II)-catalyzed decarboxylation/elimination of N-arylsulfonyl amino acids to primary aryl sulfonamides

A novel protocol for CuO-catalyzed decarboxylation/elimination of N-arylsulfonyl amino acids was developed. It is the first example of using an accessible amino acid as an ammonia synthetic equivalent for the synthesis of primary aryl sulfonamides via oxidative decarboxylation/elimination reactions. The present protocol shows excellent functional group tolerance and provides an efficient method for the synthesis of primary aryl sulfonamides in excellent yields.

N-Acyl arylsulfonamides as novel, reversible inhibitors of human steroid sulfatase

Steroid sulfatase (STS) is an attractive target for a range of oestrogen- and androgen-dependent diseases. In search of novel chemotypes of STS inhibitors, we had previously identified nortropinyl-arylsulfonylureas 1; however, while these compounds were good inhibitors of purified STS (lowest Ki = 76 nM), they showed only weak inhibition of STS activity in cells (lowest IC50 around 2 μM). Extended structure-activity relationship studies involving modification of the phenylacetyl side chain and replacement of the nortropine element by simpler scaffolds led to the discovery of N-acyl arylsulfonamides, more specifically N-(Boc-piperidine-4-carbonyl)- benzenesulfonamides, as STS inhibitors, some of which exhibit improved cellular potency (best IC50 = 270 nM).