19797-85-4

Upstream product

• 719-80-2 Ethyl diphenylphosphinite 
• 99-73-0 para-bromophenacyl bromide 
• 766-96-1 4-bromo-1-ethynylbenzene 
• 4559-70-0 Diphenylphosphine oxide 
• 33170-68-2 1,3-bis-(4-bromo-phenyl)-propane-1,3-dione 
• 4023-81-8 1-(p-bromophenyl)-1,3-butanedione 
• 1200-07-3 3-(4-bromophenyl)acrylic acid 
• 2039-82-9 1-bromo-4-ethenyl-benzene 
• 299456-72-7 1-(4-bromophenyl)ethanone O-acetyl oxime 
• 25294-65-9 3-(4-bromophenyl)-2-propynoic acid 
• 108-86-1 bromobenzene 
• 99-90-1 para-bromoacetophenone 
• 59862-55-4 p-bromoacetophenone oxime 

Downstream Products

• 23040-07-5 Diphenylphosphinyl-(4-brom-benzoyl)-diazomethan 
• 1351165-66-6 [2-(4-bromophenyl)ethynyl]diphenylphosphine oxide 

Relevant academic research and scientific papers

Metal-free oxidative phosphinylation of aryl alkynes to β-ketophosphine oxides via visible-light photoredox catalysis

A method for photocatalytic oxidative coupling of diaryl phosphine oxide and arylacetylene under mild conditions was developed. Rhodamine B, an inexpensive and commercially available organic dye, was used as the photocatalyst. This protocol realizes a reg

Silver-Catalyzed Oxyphosphorylation of Unactivated Alkynes

Here, we describe an application of hydroazidation in the instant activation of alkynes for achieving the oxyphosphorylation of unactivated alkynes with diarylphosphinoyl radicals under mild reaction conditions. This reaction provides a method for accessing β-ketophosphine oxides and phosphorus-containing pyrroles. (Figure presented.).

Iron-Catalyzed and Air-Mediated C(sp3)?H Phosphorylation of 1,3-Dicarbonyl Compounds Involving C?C Bond Cleavage

A C(sp3)?H phosphorylation has been achieved via the iron-catalyzed cross-coupling reactions between 1,3-dicarbonyl compounds and P(O)?H compounds involving C?C bond cleavages with air as the oxidant. This transformation provides a straightforward way to construct C(sp3)?P bonds, leading to the formation of β-ketophosphine oxides in up to 93% yield with good functional group tolerance. (Figure presented.).

Direct synthesis of β-ketophosphine oxides via copper-catalyzed difunctionalization of alkenes with H-phosphine oxides and dioxygen

A simple copper-catalyzed direct difunctionalization of alkenes with H-phosphine oxides and dioxygen for the synthesis of β-ketophosphine oxides has been developed under mild conditions. The present protocol, which utilizes an inexpensive catalyst, readily available materials, and environmentally benign oxygen source, provides a convenient and cost-effective approach to construct various β-ketophosphine oxides.

Base-Promoted Direct Oxyphosphorylation of Alkynes with H-Phosphine Oxides in the Presence of Water

We have developed a simple method for the oxyphosphorylation of arylalkynes to give β-keto phosphine oxides without the assistance of any transition metal. An inorganic base promoted the oxyphosphorylation and water played a synergistic role in the formation of various β-keto phosphine oxides. The reaction showed a wide structural scope and broad functional-group tolerance, and it proceeded under mild reaction conditions. This method solved the problem of metal dependence in the oxyphosphorylation of alkynes, providing a potential application in organic chemistry. Control experiments revealed the mechanism of the oxyphosphorylation and the synergistic role played by water in the radical process.

Visible Light-Mediated Photocatalytic Metal-Free Cross-Coupling Reaction of Alkenyl Carboxylic Acids with Diarylphosphine Oxides Leading to β-Ketophosphine Oxides

A new visible light-mediated photocatalytic decarboxylative oxyphosphorylation of cinnamic acids with diarylphosphine oxides is described. This reaction is performed under mild conditions to afford the corresponding β-ketophosphine oxides.

INTRODUCTION REACTION OF OH GROUP AND C=O GROUP

PROBLEM TO BE SOLVED: To provide an introduction reaction of a phosphoryl group and an OH group or a C=O group to alkene. SOLUTION: There is provided a manufacturing method of a product to which a phosphoryl group and an OH group or a C=O group are introduced, including a novel compound applicable to various substrates and thought to have high utility by reacting alkene and a phosphorus compound in presence of oxygen. The manufacturing method makes available to (1) reduce a residual halogen component and a residual metal component in the product, (2) easily obtain an OH group introduced compound and a C=O group introduced compound by using an oxidant and a reductant, i.e. produce 100% target and (3) reduce manufacturing cost, compared to conventional manufacturing methods. SELECTED DRAWING: None COPYRIGHT: (C)2017,JPOandINPIT

Solvent-controlled direct radical oxyphosphorylation of styrenes mediated by Manganese(III)

Direct radical oxyphosphorylation of styrenes with diarylphosphine oxides and dialkyl phosphites mediated by Mn(OAc)3 is described. The solvent played a key role in this selective difunctionalization reaction.

Copper-catalyzed direct oxyphosphorylation of alkynes with H-phosphine oxides and dioxygen: A convenient approach to β-ketophosphine oxides

A simple and facile copper-catalyzed synthesis of β-ketophosphine oxides via direct oxyphosphorylation of alkynes with H-phosphine oxides and dioxygen has been developed under mild conditions without any base or cocatalyst. A radical reaction pathway for

Dioxygen-induced oxidative activation of a P-H bond: Radical oxyphosphorylation of alkenes and alkynes toward β-oxy phosphonates

The dioxygen-induced radical oxyphosphorylation of alkenes and alkynes is presented, wherein a P-H bond was activated by molecular oxygen. Various β-oxy phosphonates could be facilely synthesized without the assistance of any transition metals or extra or