198017-49-1

Upstream product

• 120-43-4 4-ethoxycarbonylpiperazine 
• 187242-88-2 2-chloro-3-nitro-6-phenylpyridine 
• 1131-80-2 (E)-3-(N,N-dimethylamino)-1-phenyl-2-propen-1-one 
• 198017-46-8 ethyl (E)-4-(1-amino-2-nitroethene-1-yl)-1-piperazinocarboxylate 
• 102266-15-9 2-amino-3-nitro-6-phenylpyridine 

Downstream Products

• 198017-51-5 ethyl 4-(3-ethylamino-6-phenyl-2-pyridyl)-1-piperazinocarboxylate 
• 198017-52-6 1-(3-ethylamino-6-phenyl-2-pyridyl)piperazine 
• 198017-50-4 ethyl 4-(3-amino-6-phenyl-2-pyridyl)-1-piperazinocarboxylate 

Relevant academic research and scientific papers

Synthesis of 6-Phenyl-Atevirdine

The synthesis of 6-phenyl-atevirdine (17), a lipophilic derivative of the potent HIV-1 reverse transcriptase inhibitor atevirdine (1), is described. The title compound was prepared from dithioacetale 2 via keteneaminal 4 and the nitropyridine derivative 10. Unexpectedly, no anti HIV activity was observed for the novel atevirdine derivative 17. The key intermediates 6, 8 and 10 could also be prepared from keteneaminal 18 via chloropyridines 22-24.