187242-88-2

Basic information

• Product Name: 2-chloro-3-nitro-6-phenylpyridine
• Synonyms: 2-chloro-3-nitro-6-phenylpyridine;EOS-60527
• CAS NO: 187242-88-2
• Molecular Formula: C₁₁H₇ClN₂O₂
• Molecular Weight: 234.63848
• Mol File: 187242-88-2.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 376.1±37.0 °C(Predicted)
• Appearance: /
• Density: 1.366±0.06 g/cm3(Predicted)
• Storage Temp.: Inert atmosphere,Room Temperature
• PKA: -4.20±0.10(Predicted)
• CAS DataBase Reference: 2-chloro-3-nitro-6-phenylpyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-chloro-3-nitro-6-phenylpyridine(187242-88-2)
• EPA Substance Registry System: 2-chloro-3-nitro-6-phenylpyridine(187242-88-2)

Safety Data

• Hazardous Substances Data: 187242-88-2(Hazardous Substances Data)

Usage

General Description

2-chloro-3-nitro-6-phenylpyridine is an organic compound with a molecular formula C11H7ClN2O2. It is a yellow solid that is insoluble in water but soluble in organic solvents. This chemical is commonly used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. It is also used in research and development, as well as in the manufacturing of dyes and pigments. 2-chloro-3-nitro-6-phenylpyridine is known to be a potential irritant and harmful if swallowed or inhaled, and proper handling and safety precautions should be taken when working with this compound.

Upstream product

• 39258-93-0 3-nitro-6-phenylpyridin-2(1H)-one 
• 92138-35-7 6-chloro-3-nitro-1H-pyridin-2-one 
• 27048-04-0 2-amino-6-chloro-3-nitropyridine 
• 98-80-6 phenylboronic acid 
• 5467-74-3 4-Bromophenylboronic acid 
• 1430341-84-6 6-bromo-2-chloro-3-nitropyridine 
• 16013-85-7 2,6-dicholoro-3-nitropyridine 
• 1131-80-2 (E)-3-(N,N-dimethylamino)-1-phenyl-2-propen-1-one 

Downstream Products

• 1439394-30-5 tert-butyl(1-(4-((3-amino-6-phenylpyridin-2-yl)amino)phenyl)cyclobutyl)carbamate 
• 1313881-69-4 tert-butyl (1-(4-(2-(2-aminopyridin-3-yl)-5-phenyl-3H-imidazo[4,5-b]pyridin-3-yl)phenyl)cyclobutyl)carbamate 
• 1313881-70-7 3-(3-(4-(1-aminocyclobutyl)phenyl)-5-phenyl-3H-imidazo[4,5-b]pyridin-2-yl)pyridin-2-amine 
• 1439394-28-1 tert-butyl (1-(4-((3-nitro-6-phenylpyridin-2-yl)amino)phenyl)cyclobutyl)carbamate 
• 198017-51-5 ethyl 4-(3-ethylamino-6-phenyl-2-pyridyl)-1-piperazinocarboxylate 
• 198017-50-4 ethyl 4-(3-amino-6-phenyl-2-pyridyl)-1-piperazinocarboxylate 
• 198017-52-6 1-(3-ethylamino-6-phenyl-2-pyridyl)piperazine 
• 198017-49-1 ethyl 4-(3-nitro-6-phenyl-2-pyridyl)-1-piperazinocarboxylate 

Relevant articles and documents

Compound for organic electroluminescent device

The invention provides a compound for an organic electroluminescent device. The compound is characterized in that a structural formula of the compound is shown as a formula (I) in the description. Thecompound provided by the invention is applied to an org

Ortho-(Dimesitylboryl)phenylphosphines: Positive boryl effect in the palladium-catalyzed suzuki-miyaura coupling of 2-chloropyridines

Catalytic systems combining ortho-(dimesitylboryl) phenylphosphines and palladium precursors have been evaluated in the Suzuki-Miyaura couplings of chloro-N-heterocycles, in particular 2-chloro pyridines, with arylboronic acids. The Lewis basic character of the substrates does not interfere with the Lewis acidic site of the ligands, even for a substrate featuring free NH2 groups. The influence of several reaction parameters has been studied and the ortho-dimesitylboryl moiety was actually found to substantially enhance the catalytic performance. The role of this group has been examined using preformed phosphine-borane/Pd complexes and the formation of an original phosphine/h4-boratabutadiene complex has been identified as a possible deactivation pathway. Regioselective coupling of 2,6-dichloro-3-nitropyridine with phosphine-borane/Pd catalysts has also been explored, and sequential double cross-couplings were found to give a direct and efficient access to unsymmetrical 2,6-diarylpyridines.

Versatile synthesis of 6-substituted 8-deazapteridine-2,4-diamines. Formal total synthesis of 8,10-dideazaminopterin

A new synthesis of 4-amino-4-deoxy-8,10-dideazapteroic acid (11d) and 6-substituted and 5,6-anellated 8-deazapteridine-2,4-diamines, 10a, 10d, 25, is described. Starting from keteneaminals 1 or 12 and enaminones 4 or β-aminoketone 17 the title compounds can be prepared via functional group transformation of 2-amino-3-nitropyridines 5 or nicotinate 13a yielding 3-amino-α-picolinonitriles 9 which are cyclocondensed with guanidine.