1983-50-2

Basic information

• Product Name: PHENYL-(4-TRIMETHYLSILANYLMETHYL-PHENYL)-METHANONE
• Synonyms: PHENYL-(4-TRIMETHYLSILANYLMETHYL-PHENYL)-METHANONE
• CAS NO: 1983-50-2
• Molecular Formula: C₁₇H₂₀OSi
• Molecular Weight: 268.4256
• Product Categories: pharmacetical
• Mol File: 1983-50-2.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: PHENYL-(4-TRIMETHYLSILANYLMETHYL-PHENYL)-METHANONE(CAS DataBase Reference)
• NIST Chemistry Reference: PHENYL-(4-TRIMETHYLSILANYLMETHYL-PHENYL)-METHANONE(1983-50-2)
• EPA Substance Registry System: PHENYL-(4-TRIMETHYLSILANYLMETHYL-PHENYL)-METHANONE(1983-50-2)

Safety Data

• Hazardous Substances Data: 1983-50-2(Hazardous Substances Data)

Upstream product

• 770-09-2 benzyltrimethylsilane 
• 98-88-4 benzoyl chloride 
• 90-90-4 (4-bromophenyl)(phenyl)methanone 
• 1822-00-0 trimethylsilylmethyllithium 
• 4206-67-1 iodo(trimethylsilyl)methane 
• 6136-66-9 4-iodobenzophenone 

Relevant articles and documents

Synthesis of functionalized benzylsilanes from arylzinc compounds and (iodomethyl)trimethylsilane by means of a novel Rh catalysis

The catalytic activity of a Rh complex in cross-coupling between ArZnI and TMSCH2l was examined in which the Rh complex, generated in situ from [RhCl(1,5-cyclooctadiene)]2 and 1,1′-bis(diphenylphosphino)- ferrocene, exhibited excellent catalytic activity for the production of various functionalized benzylsilanes in good yields. From 31P NMR studies of various solutions containing several of the reaction components, confirmation of the rapid and quantitative transfer of aryl groups from ArZnI to the Rh complex to form arylrhodium species was ascertained. A catalytic cycle, commencing with the transmetalation, was thus proposed for the reaction.

Palladium-Catalyzed Arylation of Polar Organometallics Mediated by 9-Methoxy-9-Borabicyclononane: Suzuki Reactions of Extended Scope

An alternative way for performing Suzuki reactions is presented.The necessary borate is the actual nucleophile in these palladium catalyzed C-C-bond formations is prepared from 9-methoxy-9-borabicyclononane (9-OMe-9-BBN) and a polar organometallic reagent RM, and not as usually from a borane and a base.This approach allows cross couplings of aryl halides with e.g. alkynyl-, methyl-, or TMSCH2-groups, which were beyond the scope of the conventional Suzuki reaction.The method is highly chemoselective and turned out to be compatible with aldehyde-, amide-, ketone-, ester- and cyano functions as well as with basic nitrogen atoms in the substrates.It was applied to the synthesis of the acetylenic natural products junipal (9a) and eutypine methyl ether (10).Since 11B NMR studies revealed that the 9-OMe-9-BBN only serves as a shuttle for delivering the RM reagent but remains unchanged during the course of the reaction, it has been possible to device the first Suzuki-type reaction sub-stoichiometric in boron.This "catalytic" protocol was used to prepare compound 8 which is highly valuable for its chemoluminescence properties.