198344-48-8

Upstream product

• 878194-06-0 (R)-pentafluorophenyl 2-phenylpropionate 
• 86217-38-1 4-phenyl-2-oxazolidinone 
• 7782-26-5 (R)-2-Phenylpropionic acid 
• 214492-02-1 (4R)-3-((2S)-2-phenylpropionyl)-4-phenyl-oxazolidin-2-one 
• 311310-18-6 (4S,2'R)-4-iso-propyl-3-(2'-phenylpropionyl)oxazolidin-2-one 
• 219951-25-4 (+/-)-pentafluorophenyl 2-phenylpropionate 
• 90319-52-1 (4R)-phenyl-2-oxazolidinone 
• 17016-83-0 (4S)-4-isopropyl-1,3-oxazolidin-2-one 
• 54705-41-8 (5R)-5-phenyl-1,3-oxazolidin-2-one 
• 90719-32-7 (S)-4-Benzyl-2-oxazolidinone 
• 492-37-5 hydratropic acid 
• 25145-43-1 2-phenylpropionyl chloride 

Downstream Products

• 28645-07-0 (S)-methyl 2-phenylpropanoate 
• 2328-26-9 methyl (R)-2-phenylpropanoate 
• 157239-52-6 propyl ester of (R)-2-phenylpropanoic acid 
• 1123-85-9 (+)-(R)-2-phenylpropanol 

Relevant academic research and scientific papers

Efficient parallel resolution of pentafluorophenyl active esters using quasi-enantiomeric combinations of oxazolidin-2-ones

The parallel resolution of racemic pentafluorophenyl 2-aryl/ phenylpropanoates and butanoates using an equimolar combination of quasi-enantiomeric Evans oxazolidin-2-ones is discussed. The levels of diastereoselectivity were excellent (>90% de) leading to separable quasi-enantiomeric oxazolidin-2-ones in good yield. This methodology was used to resolve a series of structurally related 2-aryl/phenylpropanoic and butanoic acids.

Resolution of pentafluorophenyl 2-phenylpropanoate using combinations of quasi-enantiomeric oxazolidin-2-ones

The kinetic, mutual and parallel resolution of a series of structurally related active esters derived from 2-phenylpropanoic acid using a combination of quasi-enantiomeric oxazolidin-2-ones is discussed.

Parallel kinetic resolution of racemic oxazolidinones using quasi-enantiomeric active esters

Racemic Evans' oxazolidinones were efficiently resolved using a combination of quasi-enantiomeric profens. The levels of stereocontrol were high, leading to products with predictable configurations.

Investigations into the parallel kinetic resolution of 2-phenylpropanoyl chloride using quasi-enantiomeric oxazolidinones

The resolution of 2-phenylpropanoyl chloride using an equimolar combination of quasi-enantiomeric oxazolidinones is discussed. The levels of diastereoselectivity were found to be dependent upon the structural nature of the metallated oxazolidinone, temperature and metal counter-ion.