878194-06-0

Basic information

• Product Name: (R)-pentafluorophenyl 2-phenylpropionate
• Synonyms: (R)-pentafluorophenyl 2-phenylpropionate
• CAS NO: 878194-06-0
• Molecular Weight: 316.227
• Mol File: 878194-06-0.mol

Chemical Properties

• CAS DataBase Reference: (R)-pentafluorophenyl 2-phenylpropionate(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-pentafluorophenyl 2-phenylpropionate(878194-06-0)
• EPA Substance Registry System: (R)-pentafluorophenyl 2-phenylpropionate(878194-06-0)

Safety Data

• Hazardous Substances Data: 878194-06-0(Hazardous Substances Data)

Upstream product

• 352534-92-0 (S)-4,5,5-triphenyl-oxazolidin-2-one 
• 219951-25-4 (+/-)-pentafluorophenyl 2-phenylpropionate 
• 190970-57-1 (S)-4-phenyl-1,3-oxazolidine-2-thione 
• 54705-42-9 (S)-4-tert-butyloxazolidin-2-one 
• 77943-39-6 4-methyl-5-phenyloxazolidin-2-one 
• 311310-18-6 (4S,2'R)-4-iso-propyl-3-(2'-phenylpropionyl)oxazolidin-2-one 
• 264621-69-4 ethyl (S)-2-oxooxazolidinine-4-carboxylate 
• 191090-38-7 (S)-(-)-5-benzyl-4,4-diphenyl-1,3-oxazolidinone 
• 184346-45-0 (S)-5,5-Diphenyl-4-isopropyl-1,3-oxazolidin-2-one 
• 86286-50-2 (4R,5S)-4,5-diphenyl-1,3-oxazolidin-2-one 

Downstream Products

• 214492-01-0 (4S,2'S)-4-isopropyl-3-(2'-phenylpropanoyl)oxazolidin-2-one 
• 311310-18-6 (4S,2'R)-4-iso-propyl-3-(2'-phenylpropionyl)oxazolidin-2-one 
• 177697-55-1 (4S)-4-phenyl-3-[(2R)-2-phenylpropionyl]oxazolidin-2-one 
• 198344-48-8 (4R,2'R)-3-(2'-phenylpropionyl)-4-phenyl-oxazolidin-2-one 
• 214492-00-9 (4R)-4-benzyl-3-[(2R)-2-phenylpropionyl]oxazolidin-2-one 
• 198344-47-7 (4R,5S)-4-methyl-5-phenyl-3-[(2R)-2-phenylpropionyl]oxazolidin-2-one 
• 1220165-39-8 C₂₄H₂₂N₂OS 
• 1262241-07-5 C₂₄H₂₂N₂OS 
• 1262241-06-4 C₂₉H₂₆N₂O₂S 

Relevant articles and documents

Resolution of pentafluorophenyl 2-phenylpropanoate using combinations of quasi-enantiomeric oxazolidin-2-ones

The kinetic, mutual and parallel resolution of a series of structurally related active esters derived from 2-phenylpropanoic acid using a combination of quasi-enantiomeric oxazolidin-2-ones is discussed.

Resolution of pentafluorophenyl esters using oxazolidin-2-ones

A series of structurally related racemic pentafluorophenyl active esters were resolved using an equimolar amount of (S)-4-phenyloxazolidin-2-one. The levels of diastereocontrol were found to be excellent (80-96% de) at ～40% conversion.

Resolution of pentafluorophenyl active esters using (S)-4-phenyloxazolidin- 2-thione

A series of structurally related racemic pentafluorophenyl active esters were resolved using an equimolar amount of (S)-4- phenyloxazolidin-2-thione. The levels of diastereocontrol were found to be excellent (>86% de at -30% conversion).

Parallel kinetic resolution of active esters using a quasi-enantiomeric combination of (R)-4-phenyl-oxazolidin-2-one and (S)-4,5,5-triphenyl-oxazolidin-2-one

The parallel kinetic resolution of a series of racemic pentafluorophenyl 2-(4-aryl/phenyl)-propionates and -butanoates using a quasi-enantiomeric combination of (R)-4-phenyl-oxazolidin-2-one and (S)-4,5,5-triphenyl-oxazolidin-2-one is discussed. The levels of diastereoselectivity were excellent (86-98% de) leading to separable quasi-enantiomeric oxazolidin-2-one adducts in good yield. This methodology was used to resolve 2-phenyl propionic acid.