1984-38-9

Usage

InChI:InChI=1/C11H12N2O4/c1-7(14)13-9-4-2-8(3-5-9)11(17)12-6-10(15)16/h2-5H,6H2,1H3,(H,12,17)(H,13,14)(H,15,16)

Upstream product

• 556-08-1 p-(acetylamino)benzoic acid 
• 61-78-9 p-Aminohippuric acid 
• 75-36-5 acetyl chloride 
• 64480-74-6 p-acetaminohippuric acid methyl ester 

Downstream Products

• 904664-91-1 2-(4-acetylaminophenyl)-4-(2-nitrobezylidene)-4,5-dihydrooxazol-5-one 
• 64480-74-6 p-acetaminohippuric acid methyl ester 
• 904665-06-1 N-[1-hydrazinocarbonyl-2-(2-nitrophenyl)vinyl]-4-acetylaminobenzamide 
• 904665-28-7 3-(4-acetylaminophenyl)-5-(2-aminobenzyl)-1H-[1,2,4]triazin-6-one 
• 904665-20-9 3-(4-acetylaminophenyl)-5-(2-nitrobenzyl)-1H-[1,2,4]triazine-6-one 
• 14511-12-7 2-(4-acetylamino-phenyl)-4-(2,6-dimethyl-pyran-4-ylidene)-4H-oxazol-5-one 

Relevant academic research and scientific papers

Identification of urinary metabolites of orally administered N,N-dimethyl-p-toluidine in male F344 rats

The metabolism of orally administered N,N-dimethyl-p-toluidine (DMPT) in male F344 rats was investigated. The rat urinary metabolite profile was determined by analytical reverse-phase high performance liquid chromatography (HPLC). Four radiolabeled peaks were observed, isolated, and purified by solid-phase extraction (SPE) and preparative HPLC methods. The 4 peaks were identified as p-(N-acetylhydroxyamino)hippuric acid (M1), DMPT N-oxide (M2), N-methyl-p-toluidine (M3), and parent DMPT. Metabolites M1 and M2 were identified by spectrometric and spectroscopic methods, including mass fragmentation pattern identification from both liquid chromatography/mass spectrometry and gas chromatography/mass spectrometry, and from chemical analysis of nuclear magnetic resonance spectra. Structural confirmation of metabolite M2 was accomplished by comparison with a synthetic standard. Peaks M3 and the peak suspected to be DMPT were identified by comparison of their HPLC retention times and mass fragmentation patterns with authentic standards of N-methyl-p-toluidine and DMPT, respectively. DMPT metabolism is similar to that reported for N,N-dimethylaniline. Copyright Taylor & Francis Group, LLC.

Biomimetic catalysis of intermodular aminoacyl transfer

Intermodular aminoacyl transfer is the fundamental bond-forming reaction in the biosynthesis of polypeptides by ribosomes and nonribosomal peptide synthetases (NRPS). Here we report the design and functional characterizations of short synthetic α-helical