3678-72-6

Basic information

• Product Name: 4-DIPHENYLMETHYLPYRIDINE
• Synonyms: 4-DIPHENYLMETHYLPYRIDINE;DIPHENYL-4-PYRIDYLMETHANE;4-(diphenylmethyl)-pyridin;4-benzhydrylpyridine;4-(DIPHENYLMETHYL)PYRIDINE HYDROCHLORIDE 99%;Diphenyl-4-pyridylmethane 99%
• CAS NO: 3678-72-6
• Molecular Formula: C₁₈H₁₅N
• Molecular Weight: 245.32
• EINECS: 222-955-4
• Product Categories: Heterocyclic Compounds
• Mol File: 3678-72-6.mol
• Article Data: 15

Chemical Properties

• Melting Point: 124-126 °C(lit.)
• Boiling Point: 378.2°Cat760mmHg
• Flash Point: 163.8°C
• Appearance: /
• Density: 1.085g/cm³
• Vapor Pressure: 1.39E-05mmHg at 25°C
• Refractive Index: 1.607
• PKA: 5.54±0.10(Predicted)
• CAS DataBase Reference: 4-DIPHENYLMETHYLPYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-DIPHENYLMETHYLPYRIDINE(3678-72-6)
• EPA Substance Registry System: 4-DIPHENYLMETHYLPYRIDINE(3678-72-6)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-37/39
• WGK Germany: 3
• Hazardous Substances Data: 3678-72-6(Hazardous Substances Data)

Usage

General Description

4-DIPHENYLMETHYLPYRIDINE, also known as DPHMP, is a chemical compound with the molecular formula C20H17N. It is a pyridine derivative that contains a diphenylmethyl group attached to the pyridine ring. DPHMP is a white to off-white crystalline powder that is insoluble in water but soluble in organic solvents. It is commonly used as a ligand in organic synthesis and as an intermediate in the production of pharmaceuticals and agrochemicals. Additionally, it has been studied for its potential use in various medicinal applications, including as an anti-inflammatory and antioxidant agent.

InChI:InChI=1/C18H15N/c1-3-7-15(8-4-1)18(16-9-5-2-6-10-16)17-11-13-19-14-12-17/h1-14,18H

Upstream product

• 626-61-9 4-Chloropyridine 
• 86-29-3 Diphenylacetonitrile 
• 100-48-1 pyridine-4-carbonitrile 
• 117-34-0 2,2-diphenylacetic acid 
• 63591-86-6 1,3-dioxoisoindolin-2-yl 2,2-diphenylacetate 
• 776-74-9 Bromodiphenylmethane 
• 2116-65-6 4-benzyl pyridine 
• 462-06-6 fluorobenzene 
• 101-81-5 Diphenylmethane 
• 1620-30-0 diphenyl(pyridin-4-yl)methanol 
• 10034-85-2 hydrogen iodide 
• 108-90-7 chlorobenzene 
• 872-85-5 pyridine-4-carbaldehyde 
• 71-43-2 benzene 

Downstream Products

• 109975-60-2 2,2-diphenyl-2-(4-pyridyl)ethanol 
• 29958-05-2 4-(2-chloro-1,1-diphenylethyl)pyridine 
• 109975-58-8 2-(4-methylphenyl)-1,1-diphenyl-1-(4-pyridyl)ethane 
• 1235721-19-3 Se-methyl 4-(diphenylmethylidene)-4H-azine-N-selenocarbamate 
• 1620-30-0 diphenyl(pyridin-4-yl)methanol 
• 1522267-99-7 (diphenyl-4-pyridyl-methane)H[trans-RuCl₄(diphenyl-4-pyridyl-methane)] 
• 1353894-17-3 trans-[diphenyl-4-pyridylmethane(+1H)][RuCl₄(dimethylsulfoxide)(diphenyl-4-pyridylmethane)] 
• 1353894-18-4 trans-Na[RuCl₄(dimethylsulfoxide)(diphenyl-4-pyridylmethane)] 
• 26344-73-0 4-(diphenylmethyl)piperidine hydrochloride 
• 1916-49-0 4-benzhydrylidene-1-methyl-1,4-dihydro-pyridine 
• 5704-22-3 4-(diphenylmethyl)-1-methylpiperidine 
• 42362-54-9 4-(chloro-diphenyl-methyl)-pyridine 
• 19841-73-7 4-(Diphenylmethyl)piperidine 
• 72964-97-7 4-benzhydryl-1-methyl-pyridinium; iodide 

Relevant articles and documents

Metal-Free Heterogeneous Semiconductor for Visible-Light Photocatalytic Decarboxylation of Carboxylic Acids

A suitable protocol for the photocatalytic decarboxylation of carboxylic acids was developed with metal-free ceramic boron carbon nitrides (BCN). With visible light irradiation, BCN oxidize carboxylic acids to give carbon-centered radicals, which were trapped by hydrogen atom donors or employed in the construction of the carbon-carbon bond. In this system, both (hetero)aromatic and aliphatic acids proceed the decarboxylation smoothly, and C-H, C-D, and C-C bonds are formed in moderate to high yields (35 examples, yield up to 93%). Control experiments support a radical process, and isotopic experiments show that methanol is employed as the hydrogen atom donor. Recycle tests and gram-scale reaction elucidate the practicability of the heterogeneous ceramic BCN photoredox system. It provides an alternative to homogeneous catalysts in the valuable carbon radical intermediates formation. Moreover, the metal-free system is also applicable to late-stage functionalization of anti-inflammatory drugs, such as naproxen and ibuprofen, which enrich the chemical toolbox.

Nickel-Catalyzed C(sp3)-H Arylation of Diarylmethane Derivatives with Aryl Fluorides

A novel nickel-catalyzed C(sp3)-H arylation with nonactivated aryl fluorides is reported. The use of 1,3-bis(2,4,6-trimethylphenyl)imidazol-2-ylidene (IMes) as a ligand was found to be critical to the success of the reaction. This new method enables the synthesis of a wide range of triarylmethane derivatives.

LDA-Mediated Synthesis of Triarylmethanes by Arylation of Diarylmethanes with Fluoroarenes at Room Temperature

A practical and convenient approach for the secondary C(sp3)-H arylation of diarylmethanes with various fluoroarenes is described. The reaction proceeds smoothly in the presence of LDA (lithium diisopropylamide) at room temperature and affords triarylmethanes in moderate to high yields.