198481-47-9Relevant academic research and scientific papers
Potent antiinflammatory 3-thiazole-4(5)-acetic acids of 1,2-benzoisothiazole
Sharma, Pawan K.,Sawhney
, p. 2427 - 2430 (1997)
A number of 1,2-benzisothiazole derivatives, having 2-thiazolyl-4(5)-acetic acid moiety attached to position-3 of 1,2-benzisothiazole nucleus, were prepared and evaluated as antiinflammatory agents. Some of these were found to possess excellent level of antiinflammatory activity in carrageenin-induced rat paw edema assay.
Synthesis and antiinflammatory activity of some 3-(2-thiazolyl)-1,2-benzisothiazoles
Sharma, Pawan K.,Sawhney,Gupta, Asha,Singh,Bani, Sarang
, p. 376 - 381 (2007/10/03)
Four types of benzisothiazole derivatives, 3-(4-alkyl/aryl-2-thiazolyl)/1,2-benzisothiazoles 1a-f 3-(4-aryl-5-carboxymethyl-2-thiazolyl)-1,2-benzisothiazoles 2, 3-(4-carboxymethyl-2-thiazolyl)-1,2-benzisothiazole 3 and 3-(5-acetyl-4-methyl-2-thiazolyl)-1,2-benzisothiazole 1g have been synthesized as potential antiinflammatory agents. All the target compounds and some selected intermediates have been assayed for their antiinflammatory activity. some of these compounds possess excellent level of antiinflammatory activity.
