Potent antiinflammatory 3-thiazole-4(5)-acetic acids of 1,2-benzoisothiazole

Article abstract of DOI:10.1016/S0960-894X(97)00449-6

A number of 1,2-benzisothiazole derivatives, having 2-thiazolyl-4(5)-acetic acid moiety attached to position-3 of 1,2-benzisothiazole nucleus, were prepared and evaluated as antiinflammatory agents. Some of these were found to possess excellent level of antiinflammatory activity in carrageenin-induced rat paw edema assay.